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Investigative Ophthalmology & Visual Science, Vol 14, 108-113, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Studies on the differentiation of retinal pigmented epithelium cells in culture

GJ Chader, DA Newsome, RE Bensinger and RT Fletcher

Sephadex G-25 fractions of chick embryo extract affect the differentiation of cloned embryonic pigmented epithelial cells (PE) in culture. Both tyrosinase activity and amounts of melanin are markedly affected by the extract fractions. 5-Hydroxyindole decreased melanin accumulation in PE cells while alpha-methyl-p-tyrosine had no apparent effect on the process. Melanin disposal as well as biosynthesis may be important in controlling the accumulation of pigment in PE cells under culture conditions. Triiodothyronine greatly increased visible pigmentation and affected the morphology of cultured PE cells.


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A. Ito, K. Yamaguchi, T. Onogawa, M. Unno, T. Suzuki, T. Nishio, T. Suzuki, H. Sasano, T. Abe, and M. Tamai
Distribution of Organic Anion-Transporting Polypeptide 2 (oatp2) and oatp3 in the Rat Retina
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 858 - 863.
[Abstract] [Full Text] [PDF]


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Copyright © 1975 by the Association for Research in Vision and Ophthalmology