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Investigative Ophthalmology & Visual Science, Vol 14, 159-163, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

A rapid method for measuring miotic activity of drugs in the intact mouse eye

G Treister, S Maayani and M Sokolovsky

A rapid and precise method for evaluating the miotic activity of cholinergic drugs has been developed based on Long's method for measuring the rate of mydriasis. The rate of reversal of mydriasis developed previously in the intact mouse eye by a mild mydriatic (phenycyclidine) is used to evaluate the miotic activity. The method provides a useful tool for measuring and comparing the miotic activity of acetylcholine agonists and cholinesterase inhibitors.




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Copyright © 1975 by the Association for Research in Vision and Ophthalmology