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Investigative Ophthalmology & Visual Science, Vol 14, 299-302, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Conjunctival goblet cell density in normal subjects and in dry eye syndromes

RA Ralph

Serial sections prepared from biopsies of the deep tarsal portion of the inferior nasal conjunctival fornix in normal subjects and in patients with various dry eye syndromes were analyzed with respect to the goblet cell densities. When compared to normal subjects, individuals with keratitis sicca, Stevens-Johnson syndrome, ocular pemphigoid, and acute alkali burn all demonstrated progressively lower goblet cell densities per millimeter of epithelial surface. These disease entities can, therefore, be considered goblet cell-deficient syndromes.


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