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Investigative Ophthalmology & Visual Science, Vol 14, 302-306, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment

EH Barany

Accommodative responses to intramuscular pilocarpine were determined in four surgically aniridic vervet monkeys, before and after eight weeks of daily unilateral topical treatment with echothiophate iodide. The echothiophate-treated eyes maintained maximum myopia during the treatment course. However, after echotiophate treatment was stopped and the refraction had returned to baseline, a subsensitivity of the accommodative mechanism to pilocarpine became apparent. Normal sensitivity to pilocarpine did not return until four to five months after echothiophate treatment had been stopped.


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B. T. Gabelt, E. A. Hennes, J. L. Seeman, B. Tian, and P. L. Kaufman
H-7 Effect on Outflow Facility after Trabecular Obstruction Following Long-Term Echothiophate Treatment in Monkeys
Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2732 - 2736.
[Abstract] [Full Text] [PDF]


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Copyright © 1975 by the Association for Research in Vision and Ophthalmology