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Investigative Ophthalmology & Visual Science, Vol 14, 306-312, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The inhibiting effect of indomethacin on the disruption of the blood- aqueous barrier in the rabbit eye

CE Krakau and R Ohman

The aqueous flare (AF) of an intact rabbit eye was measured by a photoelectric instrument. Local application of prostaglandin E2 (PGE2) and its precursor arachidonic acid (AA) gave an almost identical increase of the AF. The response to AA but not to PGE2 was inhibited by pretreating the eye locally with a solution of indomethacin. The ability of indomethacin to inhibit the aqueous flare response (AFR) to an agent is assumed to indicate that a kind of prostaglandin is the effector of the AF. Indomethacin blocked the AFR to infrared irradiation of the iris and to intravenous administration of endotoxin but not to subcutaneous administration of alpha-melanocyte-stimulating hormone (alpha-MSH).


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Copyright © 1975 by the Association for Research in Vision and Ophthalmology