Investigative Ophthalmology & Visual Science, Vol 14, 517-527, Copyright © 1975 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Early cytologic changes of Fraser cataract. An electron microscopic study

Y Hamai and T Kuwabara

The cataractous lens of the Fraser strain mouse was studied electron microscopically in its early developmental stage. Cytologic abnormalities were found in the cells of the invaginating ectodermal cell of the early optic cup. Morphogenetically degenerating cells were more numerous in this stage. In general, cells of the posterior layer of the developing lens elongated normally. However, they contained great numbers of dilated rough endoplasmic reticulum, vacuoles, and mitochondria, but less amounts of crystalline substance and polysomes. During the further differentiating stage (thirteenth and fourteenth fetal day), apical portions of these cells began to swell and the lens became opaque. The swollen lens cells degenerated after this stage.

This article has been cited by other articles:

				A. De Maria and S. Bassnett DNase II Distribution and Activity in the Mouse Lens Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5638 - 5646. [Abstract] [Full Text] [PDF]

				A. J. Zandy and S. Bassnett Proteolytic Mechanisms Underlying Mitochondrial Degradation in the Ocular Lens Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 293 - 302. [Abstract] [Full Text] [PDF]

				A. J. Zandy, S. Lakhani, T. Zheng, R. A. Flavell, and S. Bassnett Role of the Executioner Caspases during Lens Development J. Biol. Chem., August 26, 2005; 280(34): 30263 - 30272. [Abstract] [Full Text] [PDF]

				J. Fan, A. K. Donovan, D. R. Ledee, P. S. Zelenka, R. N. Fariss, and A. B. Chepelinsky {gamma}E-crystallin Recruitment to the Plasma Membrane by Specific Interaction between Lens MIP/Aquaporin-0 and {gamma}E-crystallin Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 863 - 871. [Abstract] [Full Text] [PDF]

				A. SHIELS, D. MACKAY, S. BASSNETT, K. AL-GHOUL, and J. KUSZAK Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein FASEB J, November 1, 2000; 14(14): 2207 - 2212. [Abstract] [Full Text]

				N. Asano, U. Schlotzer-Schrehardt, S. Dorfler, and G. O. H. Naumann Ultrastructure of Contusion Cataract Arch Ophthalmol, February 1, 1995; 113(2): 210 - 215. [Abstract] [PDF]

				A Sandilands, A. Prescott, J. Carter, A. Hutcheson, R. Quinlan, J Richards, and P. FitzGerald Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation J. Cell Sci., January 4, 1995; 108(4): 1397 - 1406. [Abstract] [PDF]

				A. Garber, C Winkler, T Shinohara, C. King, G Inana, J Piatigorsky, and R. Gold Selective loss of a family of gene transcripts in a hereditary murine cataract Science, January 4, 1985; 227(4682): 74 - 77. [Abstract] [PDF]