Investigative Ophthalmology & Visual Science, Vol 19, 256-266, Copyright © 1980 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry

DJ Townsend and RF Brubaker

Epinephrine hydrochloride (1%) and an identical-appearing placebo were instilled into the right/left eye pairs (random assignment) of 24 young normal subjects. Aqueous humor flow (measured by fluorophotometry over a 7 hr period), intraocular pressure, and (in 10 subjects) tonographic facility of outflow were measured. The effects of epinephrine were to lower intraocular pressure (2.8 mm Hg +/- 1.9, mean +/- S.D.), raise the facility of outflow (37.4% +/- 21.7), and increase the rate of formation of aqueous humor (18.6% +/- 18.1). By comparing tonographic and fluorophotometric data in the same subjects, it was postulated that epinephrine increases the rate of outflow via the pressure-insensitive (uveoscleral, uveovortex) outflow pathway.

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