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Investigative Ophthalmology & Visual Science, Vol 19, 313-315, Copyright © 1980 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Altering the course of cataracts in diabetic rats

S Fukushi, LO Merola and JH Kinoshita

A potent new aldose reductase (AR) inhibitor was effective in preventing cataractous changes in diabetic rats. Untreated diabetic rats developed early lens changes by 3 weeks and dense nuclear opacities by 6 to 9 weeks. In contrast, diabetic rats treated with the AR inhibitor showed no lens changes during the 5-month period of the experiment.


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W. Williams and J. Odom
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy
Science, July 11, 1986; 233(4760): 223 - 225.
[Abstract] [PDF]


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Copyright © 1980 by the Association for Research in Vision and Ophthalmology