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Investigative Ophthalmology & Visual Science, Vol 19, 487-491, Copyright © 1980 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of topical l-epinephrine on regional ocular blood flow in monkeys

A Alm

A 25 microliter volume of a 1-% l-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduced blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes. In the ciliary body the main effect was in the ciliary processes. Blood flow was determined with the labeled microsphere method 1, 4, and 6 hr after application of the drug. The average blood flow reductions were of the same order in the three groups, indicating a duration of at least 6 hr. No effect on blood flow through the retina or the choroid was observed.


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T. M. Nork, C. B. Y. Kim, D. Shanmuganayagam, M. S. Van Lysel, J. N. Ver Hoeve, and J. D. Folts
Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres.
Arch Ophthalmol, June 1, 2006; 124(6): 860 - 868.
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