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Investigative Ophthalmology & Visual Science, Vol 19, 522-528, Copyright © 1980 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Thiol oxidation in the crystalline lens. I. The rate-limiting role of hexokinase in aging rat and human lenses

HM Cheng and LT Chylack Jr

Reduction of nonprotein disulfides required both glucose or glucose-6- phosphate (G6P) and nicotinamide adenine dinucleotide phosphate (NADP). However, hexokinase (HK) was found to be the rate-limiting step: the glucose-supported reduction rate was only 50% of that of G6P-supported activity. This disulfide-reducing activity seemed to decline in the aging lens. Further, the glucose-supported activity dropped substantially if HK was deactivated with diamide; the deactivation was partially reversible. HK activity in aging clear and cataractous human lenses had greatly diminished. This might explain the disproportionate decrease in glucose-supported reduction in the aging lens. The components of the disulfide-reducing mechanism in human lens were reviewed and discussed.




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Copyright © 1980 by the Association for Research in Vision and Ophthalmology