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Investigative Ophthalmology & Visual Science, Vol 20, 213-221, Copyright © 1981 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Experimental Pseudomonas keratitis in the rabbit: bacteriologic, clinical, and microscopic observations

DL Van Horn, SD Davis, RA Hyndiuk and HJ Pederson

Uniformly severe corneal infections were produced in rabbits by intracorneal injection of a few viable Pseudomonas aeruginosa. The bacteria multiplied rapidly, and within 24 hr, about 10 million organisms were present. The numbers remained stable thereafter. Polymorphonuclear leukocytes (PMNs) began to infiltrate peripheral stroma 24 hr after inoculation. By 32 hr, ring-shaped dense accumulations of PMNs were apparent in the anterior stroma with moderate stromal edema. By 48 hr, the anterior one third of central stroma was severely involved with abscess formation and loss of epithelium, and PMNs had invaded full corneal thickness. The area of liquefactive necrosis eventually involved the entire cornea from limbus to limbus, and collagen staining was lost. Transmission electron microscopy revealed the accumulation of small electron-dense particles in association with collagen fibrils and degranulating PMNs.


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Z. Dong, M. Katar, S. Alousi, and R. S. Berk
Expression of Membrane-Type Matrix Metalloproteinases 4, 5, and 6 in Mouse Corneas Infected with P. aeruginosa
Invest. Ophthalmol. Vis. Sci., December 1, 2001; 42(13): 3223 - 3227.
[Abstract] [Full Text] [PDF]

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Z. Dong, M. Ghabrial, M. Katar, R. Fridman, and R. S. Berk
Membrane-Type Matrix Metalloproteinases in Mice Intracorneally Infected with Pseudomonas aeruginosa
Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4189 - 4194.
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