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Investigative Ophthalmology & Visual Science, Vol 23, 697-714, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Chronic retinitis in rats infected as neonates with lymphocytic choriomeningitis virus: a clinical, histopathologic, and electroretinographic study

M del Cerro, DA Grover, AA Monjan, CJ Pfau and JE Dematte

The long-term sequelae to infection of neonatal rats with lymphocytic choriomeningitis virus were studied by a variety of approaches, including indirect ophthalmoscopic, electroretinographic, and histopathologic methods. Data from these studies demonstrated that a progressive chronic retinitis develops after the acute, virus-specific, immune-mediated retinopathy. This chronic inflammation eventually leads to a total destruction of the retinal architecture. An autoimmune reaction against normally sequestered retinal antigens, released during the acute state of necrotizing retinitis, is probably the initiating mechanism of the chronic disease. This experimental disease, triggered by infection with a relatively harmless virus, constitutes a very convenient animal model of chronic retinitis.


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D. J. Bonthius, J. Mahoney, M. J. Buchmeier, B. Karacay, and D. Taggard
Critical Role for Glial Cells in the Propagation and Spread of Lymphocytic Choriomeningitis Virus in the Developing Rat Brain
J. Virol., June 5, 2002; 76(13): 6618 - 6635.
[Abstract] [Full Text] [PDF]


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Copyright © 1982 by the Association for Research in Vision and Ophthalmology