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Investigative Ophthalmology & Visual Science, Vol 23, 801-804, Copyright © 1982 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Psoralen--long-wave ultraviolet therapy and human cataractogenesis

S Lerman, J Megaw and K Gardner

Cataract formation associated with psoralen--long-wave ultraviolet (P- UVA) therapy has been documented in experimental animals. Presumptive P- UVA cataracts in humans have also been reported recently. Cataracts from two patients on P-UVA therapy were subjected to high-resolution phosphorescence spectroscopy. The lens homogenates from these two patients showed phosphorescence peaks identical (in shape and lifetime) with the previously reported 8-methoxypsoralen lens protein photoproduct seen in P-UVA-treated cataractous rat lenses. The data provide objective proof that these phototherapeutic drugs can generate specific P-UVA photoproducts in human lenses. Similar photoproducts have previously been demonstrated in experimental (rat) P-UVA cataracts.




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Copyright © 1982 by the Association for Research in Vision and Ophthalmology