IOVS British Journal of Pharmacology
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Investigative Ophthalmology & Visual Science, Vol 24, 393-395, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of phenylephrine hydrochloride on the resting point of accommodation

LF Garner, B Brown, R Baker and M Colgan

Previous models for ocular accommodation have suggested a dual sympathetic/parasympathetic innervation to the ciliary muscle. Such models would predict that sympathomimetic drugs should change the resting point or dark focus of accommodation. The effect of an alpha- adrenergic agonist (10% phenylephrine hydrochloride) on accommodation was examined; the results show a decrease in the near point of accommodation, without a change in the resting point of accommodation. These results suggest that the accommodative state of the eye is not the result of a simple balance between sympathetic and parasympathetic innervation as proposed by previous models of accommodation.


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L. A. Ostrin and A. Glasser
The Effects of Phenylephrine on Pupil Diameter and Accommodation in Rhesus Monkeys
Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 215 - 221.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology