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Investigative Ophthalmology & Visual Science, Vol 24, 522-525, Copyright © 1983 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Phase separation in rat lenses cultured in low glucose media

T Tanaka, S Rubin, ST Sun, I Nishio, WH Tung and LT Chylack Jr

Experimental evidence that indicates the nuclear opacity that develops in the hypoglycemic cataract in rat lenses is the result of a phase separation of the lens cytoplasm is presented. Phase diagrams of the cytoplasm of organ-cultured lenses were constructed for a series of incubation times in normal and hypoglycemic media. In normal media, the maximum phase separation temperature, Tmax, of the lens cytoplasm decreases with time. In hypoglycemic media, Tmax increases with time and exceeds 37 C after 24 hrs. The increase in Tmax can be stopped and reversed if the lens is returned to normal media within 8 hrs; in good agreement with an earlier biochemical analysis of the kinetics of hypoglycemic cataract formation.


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Copyright © 1983 by the Association for Research in Vision and Ophthalmology