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Investigative Ophthalmology & Visual Science, Vol 27, 1516-1521, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Lectin binding to pseudoexfoliative material and the ocular zonules

BW Streeten, SA Gibson and ZY Li

Lectin staining of pseudoexfoliative material on the lens capsule, zonules, and iris showed the presence of the beta-D-galactose (1-3) galactosamine sequence, alpha-D-galactosamine, beta-D-galactose, beta- (1-4)-D-glucosamine, and terminal sialic acid. Mono and difucosyl binding sites were also found. The likelihood that the lectins were binding to two different galactosamine-containing moieties was supported by their different distributions in the photoreceptors. These affinities suggest a complex carbohydrate composition in pseudoexfoliative material, with both O-linked sialomucin-type and N- linked oligosaccharide chains.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology