IOVS Health Education Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nir, I.
Right arrow Articles by Papermaster, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nir, I.
Right arrow Articles by Papermaster, D. S.

Investigative Ophthalmology & Visual Science, Vol 27, 836-840, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immunocytochemical localization of opsin in the inner segment and ciliary plasma membrane of photoreceptors in retinas of rds mutant mice

I Nir and DS Papermaster

Homozygous 020/A mutant mice bearing the rds gene for slow inherited retinal degeneration have been observed to develop normal photoreceptor inner segments connecting cilia and synaptic contacts but fail to form outer segments. Their retinas are responsive to light, however. In order to assess the sources of these physiological responses we investigated the distribution of opsin in photoreceptors by means of immunoelectron microscopy. Opsin was detected in the inner segment plasma membrane and the distal ciliary plasma membrane. Antibody also bound to lamellar and vesicular membranes in the interphotoreceptor space and, in a small fraction of the photoreceptors, to membranes projecting from the distal cilium. These membranes may represent abortive formation of rod discs in this form of retinal degeneration. Failure to form an organized outer segment may contribute to the persistence of opsin in the inner segment plasma membranes of adult mutant mice.


This article has been cited by other articles:


Home page
 IOVSHome page
V. Chrysostomou, J. Stone, and K. Valter
Life History of Cones in the Rhodopsin-Mutant P23H-3 Rat: Evidence of Long-term Survival
Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2407 - 2416.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Zacchigna, H. Oh, M. Wilsch-Brauninger, E. Missol-Kolka, J. Jaszai, S. Jansen, N. Tanimoto, F. Tonagel, M. Seeliger, W. B. Huttner, et al.
Loss of the Cholesterol-Binding Protein Prominin-1/CD133 Causes Disk Dysmorphogenesis and Photoreceptor Degeneration
J. Neurosci., February 18, 2009; 29(7): 2297 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. Turney, N. H. V. Chong, R. A. Alexander, C. R. Hogg, L. Fleming, D. Flack, K. C. Barnett, A. C. Bird, G. E. Holder, and P. J. Luthert
Pathological and Electrophysiological Features of a Canine Cone Rod Dystrophy in the Miniature Longhaired Dachshund
Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4240 - 4249.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. Farjo, J. S. Skaggs, B. A. Nagel, A. B. Quiambao, Z. A. Nash, S. J. Fliesler, and M. I. Naash
Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
J. Cell Biol., April 10, 2006; 173(1): 59 - 68.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. A. Khodair, M. A. Zarbin, and E. Townes-Anderson
Cyclic AMP Prevents Retraction of Axon Terminals in Photoreceptors Prepared for Transplantation: An In Vitro Study
Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 967 - 973.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. S. Sethi, G. P. Lewis, S. K. Fisher, W. P. Leitner, D. L. Mann, P. J. Luthert, and D. G. Charteris
Glial Remodeling and Neural Plasticity in Human Retinal Detachment with Proliferative Vitreoretinopathy
Invest. Ophthalmol. Vis. Sci., January 1, 2005; 46(1): 329 - 342.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
G. P. Lewis, D. G. Charteris, C. S. Sethi, W. P. Leitner, K. A. Linberg, and S. K. Fisher
The Ability of Rapid Retinal Reattachment to Stop or Reverse the Cellular and Molecular Events Initiated by Detachment
Invest. Ophthalmol. Vis. Sci., July 1, 2002; 43(7): 2412 - 2420.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. D. Alfinito and E. Townes-Anderson
Activation of mislocalized opsin kills rod cells: A novel mechanism for rod cell death in retinal disease
PNAS, April 16, 2002; 99(8): 5655 - 5660.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. J. Pazour, S. A. Baker, J. A. Deane, D. G. Cole, B. L. Dickert, J. L. Rosenbaum, G. B. Witman, and J. C. Besharse
The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance
J. Cell Biol., April 1, 2002; 157(1): 103 - 114.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. A. Hagstrom, M. Adamian, M. Scimeca, B. S. Pawlyk, G. Yue, and T. Li
A Role for the Tubby-Like Protein 1 in Rhodopsin Transport
Invest. Ophthalmol. Vis. Sci., August 1, 2001; 42(9): 1955 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Nir, W. Kedzierski, J. Chen, and G. H. Travis
Expression of Bcl-2 Protects against Photoreceptor Degeneration in retinal degeneration slow (rds) Mice
J. Neurosci., March 15, 2000; 20(6): 2150 - 2154.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. K. Söderpalm, D. A. Fox, J.-O. Karlsson, and T. van Veen
Retinoic Acid Produces Rod Photoreceptor Selective Apoptosis in Developing Mammalian Retina
Invest. Ophthalmol. Vis. Sci., March 1, 2000; 41(3): 937 - 947.
[Abstract] [Full Text]

Home page
 IOVSHome page
S. A. Hagstrom, M. Duyao, M. A. North, and T. Li
Retinal Degeneration in tulp1-/- Mice: Vesicular Accumulation in the Interphotoreceptor Matrix
Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2795 - 2802.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Kedzierski, J. Weng, and G. H. Travis
Analysis of the rds/peripherin{middle dot}rom1 Complex in Transgenic Photoreceptors That Express a Chimeric Protein
J. Biol. Chem., October 8, 1999; 274(41): 29181 - 29187.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Cayouette, D. Behn, M. Sendtner, P. Lachapelle, and C. Gravel
Intraocular Gene Transfer of Ciliary Neurotrophic Factor Prevents Death and Increases Responsiveness of Rod Photoreceptors in the retinal degeneration slow mouse
J. Neurosci., November 15, 1998; 18(22): 9282 - 9293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Kedzierski, D. Bok, and G. H. Travis
Non-Cell-Autonomous Photoreceptor Degeneration in rds Mutant Mice Mosaic for Expression of a Rescue Transgene
J. Neurosci., June 1, 1998; 18(11): 4076 - 4082.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
W Kedzierski, W. Moghrabi, A. Allen, M. Jablonski-Stiemke, S. Azarian, D Bok, and G. Travis
Three homologs of rds/peripherin in Xenopus laevis photoreceptors that exhibit covalent and non-covalent interactions
J. Cell Sci., January 10, 1996; 109(10): 2551 - 2560.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. D. Alfinito and E. Townes-Anderson
Activation of mislocalized opsin kills rod cells: A novel mechanism for rod cell death in retinal disease
PNAS, April 16, 2002; 99(8): 5655 - 5660.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. J. Pazour, S. A. Baker, J. A. Deane, D. G. Cole, B. L. Dickert, J. L. Rosenbaum, G. B. Witman, and J. C. Besharse
The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance
J. Cell Biol., April 1, 2002; 157(1): 103 - 114.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the Association for Research in Vision and Ophthalmology