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Investigative Ophthalmology & Visual Science, Vol 28, 506-514, Copyright © 1987 by Association for Research in Vision and Ophthalmology
ARTICLES AND REPORTS |
T Kohno, N Sorgente, T Ishibashi, R Goodnight and SJ Ryan
The topographic distribution of fibronectin and laminin in young and old human eyes was determined by indirect immunofluorescent techniques. These two glycoproteins may play a role in the attachment of the vitreous to the internal limiting membrane (ILM) and the internal limiting membrane to the Mueller cell processes. A double-laminated pattern of fluorescence for both glycoproteins was frequently found at the ILM of the posterior retina of aged eyes. This pattern of fluorescence, which was rarely seen in young eyes, may represent senescent changes in the ILM which could predispose the eye to posterior vitreous detachment.
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