IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Small, K. W.
Right arrow Articles by Hatchell, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Small, K. W.
Right arrow Articles by Hatchell, D. L.

Investigative Ophthalmology & Visual Science, Vol 28, 672-675, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Retinal blood flow in normal and diabetic dogs

KW Small, E Stefansson and DL Hatchell

We have found retinal blood flow to be decreased in diabetic dogs 5 months after the onset of diabetes, which is long before they can be expected to develop morphological changes of diabetic retinopathy. Retinal blood flow was determined using radionuclide labelled microspheres. In eight alloxan diabetic dogs without retinopathy, the retinal blood flow was 0.53 +/- 0.08 (mean +/- SE) ml/min/gm dry tissue weight. This compares with 0.91 +/- 0.17 (mean +/- SE) ml/min/gm dry tissue weight in seven normal dogs. The decreased blood flow in diabetic retinas is statistically significant (P = 0.05). Blood glucose levels did not significantly affect retinal blood flow. This data suggest that changes in retinal blood flow and oxidative metabolism may precede the morphological signs of diabetic retinopathy.


This article has been cited by other articles:


Home page
 Vasc MedHome page
M. Meier and G. L King
Protein kinase C activation and its pharmacological inhibition in vascular disease
Vascular Medicine, August 1, 2000; 5(3): 173 - 185.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the Association for Research in Vision and Ophthalmology