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Investigative Ophthalmology & Visual Science, Vol 28, 759-762, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Iris-ciliary complex inhibits protein synthesis by organ cultured mammalian ocular lens cells

M Bagchi, AA Dave, AK Singh and MJ Caporale

Freshly isolated rabbit ocular lenses with or without adhering iris- ciliary complex were organ cultured. It was found that lenses with iris- ciliary complex showed decreased protein synthetic ability. Vimentin, a cytoskeletal protein and MP-26, a membrane associated protein, were used as markers for protein synthetic activity. Removal of the iris- ciliary complex at least partially restores the protein synthetic capability of the lens. The ocular lenses cultured with iris-ciliary complex for 48 hr showed marked equatorial opacities.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology