IOVS Is this journal stale?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by She, S. C.
Right arrow Articles by Moticka, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by She, S. C.
Right arrow Articles by Moticka, E. J.

Investigative Ophthalmology & Visual Science, Vol 31, 1950-1956, Copyright © 1990 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Intracameral injection of allogeneic lymphocytes enhances corneal graft survival

SC She, LP Steahly and EJ Moticka
Department of Surgery, Southern Illinois University, School of Medicine, Springfield 62794-9230.

Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the eye leads to an immune response characterized by normal antibody response coupled with depressed T-cell reactivity especially as measured by delayed-type hypersensitivity. To determine if this phenomenon could be used to alter the course of graft failure, potential recipients (Lewis rats) were injected intracamerally (IC) with allogeneic lymphoid cells (Wistar-Furth). Orthotopic, full-thickness, penetrating keratoplasty was done 0-30 days later, and the recipients were observed for at least 60 days. Approximately 75% of Wistar-Furth corneal grafts placed on uninjected Lewis rats failed as evidenced by continued opacity, edema, and infiltration of mononuclear cells into the grafts. The IC injection of Wistar-Furth lymphocytes decreased this failure rate to 25% and 50% when grafting was done 14 and 7 days after injection, respectively. Grafts of cornea from a third strain onto IC injected animals failed at an intermediate rate which demonstrated some immunologic protection. The results of these studies indicate that IC injection of allogeneic lymphocytes results in prolonged acceptance of corneal grafts syngeneic with the injected lymphocytes.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
H. M. Ashour and J. Y. Niederkorn
Peripheral Tolerance Via the Anterior Chamber of the Eye: Role of B Cells in MHC Class I and II Antigen Presentation
J. Immunol., May 15, 2006; 176(10): 5950 - 5957.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Y. Niederkorn
The immune privilege of corneal grafts
J. Leukoc. Biol., August 1, 2003; 74(2): 167 - 171.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Sonoda, Y. Sonoda, R. Muramatu, J. W. Streilein, and M. Usui
ACAID Induced by Allogeneic Corneal Tissue Promotes Subsequent Survival of Orthotopic Corneal Grafts
Invest. Ophthalmol. Vis. Sci., March 1, 2000; 41(3): 790 - 798.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the Association for Research in Vision and Ophthalmology