| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Investigative Ophthalmology & Visual Science, Vol 31, 2136-2144, Copyright © 1990 by Association for Research in Vision and Ophthalmology
ARTICLES AND REPORTS |
DA Lee, TC Lee, AE Cortes and S Kitada
Jules Stein Eye Institute, UCLA School of Medicine 90024-7004.
Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. Fifty percent inhibitory doses (ID50) for each drug on different days of incubation with fibroblasts were calculated with these three assays. Among these four drugs only daunorubicin exerted a significant effect on cellular attachment, showing cytotoxicity at 4 x 10(-6) M. However, all drugs had antiproliferative effects. Daunorubicin was the most potent drug in the concentration range studied. Mithramycin had a narrow therapeutic range in tissue culture. Cellular antiproliferative responses to mitomycin and bleomycin were more gradual. These drugs have potential applications in the prevention of glaucoma filtration surgery failure.
This article has been cited by other articles:
|
|
 |
|
  B. A. Francis, L. T. Du, K. Najafi, R. Murthy, U. Kurumety, N. Rao, and D. S. Minckler Histopathologic Features of Conjunctival Filtering Blebs Arch Ophthalmol, February 1, 2005; 123(2): 166 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mietz, J. M. Esser, G. Welsandt, N. Kociok, A. Hueber, A. Joussen, P. Esser, and G. K. Krieglstein Latanoprost Stimulates Secretion of Matrix Metalloproteinases in Tenon Fibroblasts Both In Vitro and In Vivo Invest. Ophthalmol. Vis. Sci., December 1, 2003; 44(12): 5182 - 5188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rahbar, D. T. Jones, R. C. Nuss, D. W. Roberson, M. A. Kenna, T. J. McGill, and G. B. Healy The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive Tract: Friend or Foe? Arch Otolaryngol Head Neck Surg, April 1, 2002; 128(4): 401 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Diestelhorst and S. Grisanti Photodynamic Therapy to Control Fibrosis in Human Glaucomatous Eyes After Trabeculectomy: A Clinical Pilot Study Arch Ophthalmol, February 1, 2002; 120(2): 130 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E G Kemp, A N Harnett, and S Chatterjee Preoperative topical and intraoperative local mitomycin C adjuvant therapy in the management of ocular surface neoplasias Br. J. Ophthalmol., January 1, 2002; 86(1): 31 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L Liao, S. C S Kao, J. H S Tseng, M. S Chen, and P. K Hou Results of intraoperative mitomycin C application in dacryocystorhinostomy Br. J. Ophthalmol., August 1, 2000; 84(8): 903 - 906. [Abstract] [Full Text]
|
|
|
|
|
|
H. Demirci, S. A. McCormick, and P. T. Finger Topical Mitomycin Chemotherapy for Conjunctival Malignant Melanoma and Primary Acquired Melanosis With Atypia: Clinical Experience With Histopathologic Observations Arch Ophthalmol, July 1, 2000; 118(7): 885 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grisanti, M. Diestelhorst, K. Heimann, and G. Krieglstein Cellular photoablation to control postoperative fibrosis in a rabbit model of filtration surgery Br. J. Ophthalmol., December 1, 1999; 83(12): 1353 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T Finger, G. Czechonska, and S. Liarikos Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia Br. J. Ophthalmol., May 1, 1998; 82(5): 476 - 479. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
