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Investigative Ophthalmology & Visual Science, Vol 31, 1321-1326, Copyright © 1990 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

In vitro evaluation of fibroplasia in a porous polymer

V Trinkaus-Randall, J Capecchi, L Sammon, D Gibbons, HM Leibowitz and C Franzblau
Boston University School of Medicine, School of Medicine, Ophthalmology Department, MA 02118.

We evaluated a polybutylene/polypropylene blend in a blown microfiber configuration in vitro for potential use as the peripheral area of a keratoprosthetic device. Material properties such as ultimate tensile strength and ultimate elongation were measured. Stromal fibroblasts were seeded onto the material in vitro, and cell proliferation between uncoated and Type I collagen coated discs did not differ significantly. Fibroblasts could be seen migrating along the fibers and also traversing the fibers. The synthesis of connective proteins was examined. Laminin, fibronectin, and Type I collagen were detected by day 8. The experiments demonstrate that stromal fibroblasts can adhere onto the fibers, proliferate, and synthesize connective tissue proteins. Experiments are now being conducted to further evaluate the material in vivo.


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