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Investigative Ophthalmology & Visual Science, Vol 31, 1474-1482, Copyright © 1990 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Changes in intermediate filament immunolabeling occur in response to retinal detachment and reattachment in primates [published erratum appears in Invest Ophthalmol Vis Sci 1990 Nov;31(11):2360]

CJ Guerin, DH Anderson and SK Fisher
Neuroscience Research Institute, University of California, Santa Barbara 93106.

The immunolabeling patterns for vimentin and glial fibrillary acidic protein (GFAP) were studied in five rhesus monkeys that had undergone retinal detachment or detachment and reattachment. Anti-vimentin and anti-GFAP labeling intensity increased in Muller cells after 2 days of detachment. Weak anti-vimentin labeling of the basal RPE cytoplasm, which was absent in control tissue, was detected 2 days after detachment. After detachment for 7 days and reattachment for 7 or 14 days, the pattern and extent of intermediate filament (IF) labeling changed. In Muller cells, the labeling, which in controls was restricted to processes near the vitreal border of the retina, was present in Muller processes spanning the entire retina. In retinal pigment epithelium (RPE) cells, prominent anti-vimentin labeling was identified in the basal and basolateral cytoplasm. The extent of RPE and Muller cell IF labeling in two animals whose retinas had been detached and then reattached for 150 days was different from that found at either the 7- or 14-day reattachment time points. This suggests that the abnormal IF distribution triggered by detachment may be attenuated after a lengthy period of reattachment.


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