IOVS Annual Reviews: Biomedical Science Suite
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uchihori, Y.
Right arrow Articles by Puro, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uchihori, Y.
Right arrow Articles by Puro, D. G.

Investigative Ophthalmology & Visual Science, Vol 32, 2689-2695, Copyright © 1991 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Mitogenic and chemotactic effects of platelet-derived growth factor on human retinal glial cells

Y Uchihori and DG Puro
Department of Ophthalmology, University of Michigan School of Medicine, Ann Arbor.

Glial cell migration and proliferation appear to play a role in many of the proliferative retinopathies. Knowledge concerning the regulation of the migratory and proliferative responses of glial cells to pathophysiologic conditions in the human retina is limited. Here, we report that platelet-derived growth factor (PDGF) has both mitogenic and chemotactic effects on human retinal glial cells in culture. These effects of PDGF support the idea that this growth factor may be one of the molecules influencing glial cell activities in the proliferative retinopathies. Both the mitogenic and chemotactic responses of retinal glial cells to PDGF could be inhibited by the calcium-channel blocker, nifedipine. Although this finding suggests that nifedipine-sensitive calcium channels may help mediate these responses to PDGF, an electrophysiologic effect of PDGF on voltage-gated calcium channels was not detected. Also, the concentration of nifedipine required to inhibit proliferation was higher than the dose needed to block calcium channels. It seems likely that nifedipine inhibits the mitogenic and chemotactic responses of human retinal glial cells to PDGF by affecting cellular processes in addition to calcium channels.


This article has been cited by other articles:


Home page
 IOVSHome page
J. L. King and C. Guidry
Insulin-Like Growth Factor Binding Proteins Modulate Muller Cell Responses to Insulin-Like Growth Factors
Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2848 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. A. Hogg, I. Grierson, and P. Hiscott
Direct Comparison of the Migration of Three Cell Types Involved in Epiretinal Membrane Formation
Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2749 - 2757.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Bringmann, S. Schopf, and A. Reichenbach
Developmental Regulation of Calcium Channel-Mediated Currents in Retinal Glial (Muller) Cells
J Neurophysiol, December 1, 2000; 84(6): 2975 - 2983.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Kodal, M. Weick, V. Moll, B. Biedermann, A. Reichenbach, and A. Bringmann
Involvement of Calcium-Activated Potassium Channels in the Regulation of DNA Synthesis in Cultured Muller Glial Cells
Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4262 - 4267.
[Abstract] [Full Text]

Home page
 IOVSHome page
L. Castelnovo, C. Dosquet, A. Gaudric, J. Sahel, and D. Hicks
Human Platelet Suspension Stimulates Porcine Retinal Glial Proliferation and Migration In Vitro
Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 601 - 609.
[Abstract] [Full Text]

Home page
 Br J OphthalmolHome page
M. Xiao, D. McLeod, J. Cranley, G. Williams, and M. Boulton
Growth factor staining patterns in the pig retina following retinal laser photocoagulation
Br J Ophthalmol, June 1, 1999; 83(6): 728 - 736.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
H. Mudhar, R. Pollock, C Wang, C. Stiles, and W. Richardson
PDGF and its receptors in the developing rodent retina and optic nerve
Development, January 6, 1993; 118(2): 539 - 552.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the Association for Research in Vision and Ophthalmology