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Investigative Ophthalmology & Visual Science, Vol 33, 1934-1939, Copyright © 1992 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

A quantitative assay of retrograde transported HSV in the trigeminal ganglion

SR Carter, L Pereira, P Paz and JH LaVail
Department of Anatomy and Neuroscience Program, University of California San Francisco 94143-0452.

The relationship between the dose of Herpes simplex virus type 1 (HSV) inoculated in the cornea and the amount of actively replicating virus recovered from mouse trigeminal ganglion cells 5 d after corneal scratch and inoculation was investigated with a tissue culture plaque assay. A dose response curve of productive viral replication was obtained. The estimated dose of HSV that produces half-maximal recovery of virus within the ganglion was 9.15 x 10(3) plaque forming units per eye, and the maximal amount of HSV recovered was 1.34 x 10(4) pfu per ganglion. This definition of infectivity as a function of dose will be useful for studying the effects of potential inhibitors of the binding, uptake, and transport of HSV by productively or latently infected trigeminal neurons.




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Copyright © 1992 by the Association for Research in Vision and Ophthalmology