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Investigative Ophthalmology & Visual Science, Vol 35, 310-313, Copyright © 1994 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model?

P Herse and B Hooker
Department of Optometry, University of Auckland, New Zealand.

PURPOSE. To compare the contact lens-induced corneal edema recovery dynamics of human subjects with type 1 diabetes with those of age- and sex-matched normal human subjects; to compare the human data with previously reported data from alloxan-induced diabetic rabbit. METHODS. Corneal edema was induced by 2 hours of closed eye wear with a thick, soft contact lens. After removal of the contact lens, central corneal thickness measurements were made at 30-minute intervals for 3 hours using optical pachometry. RESULTS. Human subjects with type 1 diabetes demonstrated a significantly slower rate of corneal edema recovery than age- and sex-matched human controls. The rate of corneal edema recovery found in this study for human subjects with type 1 diabetes is similar to that previously reported for alloxan-induced diabetic rabbits. CONCLUSIONS. The decreased corneal edema recovery ability of the patient with type 1 diabetes suggests that care should be taken when prescribing contact lens use in these people. The similarity between corneal edema recovery rates in the human subject with type 1 diabetes and the alloxan-induced diabetic rabbit supports the use of the alloxan- induced diabetic rabbit as an animal model for studies of corneal edema recovery dynamics in diabetes.


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 Arch OphthalmolHome page
S. Morikubo, Y. Takamura, E. Kubo, S. Tsuzuki, and Y. Akagi
Corneal Changes After Small-Incision Cataract Surgery in Patients With Diabetes Mellitus
Arch Ophthalmol, July 1, 2004; 122(7): 966 - 969.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the Association for Research in Vision and Ophthalmology