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Investigative Ophthalmology & Visual Science, Vol 40, 1577-1584, Copyright © 1999 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Naturally occurring vitreous chamber-based myopia in the Labrador retriever

DO Mutti, K Zadnik and CJ Murphy
School of Optometry, University of California, Berkeley 94720-2020, USA.

PURPOSE: To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS: Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature were measured in the right eyes of 57 of these dogs using a video-based keratophakometer, with axial ocular dimensions measured using A-scan ultrasonography. RESULTS: Of the 75 dogs tested, 11 (14.7%) were myopic by at least - 0.50 D in one eye, and 6 (8.0%) were myopic in both eyes (full range of refractive errors, +3.50 D to -5.00 D). Of the 57 dogs with ocular component measurements, seven (12.3%) were myopic by at least -0.50 D in the right eye. There was a significant negative correlation between refractive error and vitreous chamber depth (Spearman r = -0.42; P < 0.001). Myopic eyes had an elongated vitreous chamber depth (10.87+/- 0.34 mm for myopic dogs, 10.02+/-0.40 mm for nonmyopic dogs; P < 0.0001, Kruskal-Wallis test). There was also a significant quadratic association between lens thickness and vitreous chamber depth (P < 0.005; R2 = 0. 11), indicating that thinner lenses occurred at both shorter and longer vitreous chamber depths. CONCLUSIONS: Myopia in the Labrador retriever is analogous to human myopia in that it is caused by an elongated vitreous chamber. Thinner crystalline lenses found at longer vitreous chamber depths may be analogous to lens thinning documented in human ocular development. The Labrador retriever warrants investigation as a potential model of myopia that is naturally occurring rather than experimentally induced.


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J. Black, S. R. Browning, A. V. Collins, and J. R. Phillips
A Canine Model of Inherited Myopia: Familial Aggregation of Refractive Error in Labrador Retrievers
Invest. Ophthalmol. Vis. Sci., November 1, 2008; 49(11): 4784 - 4789.
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