| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 From the Laboratory of Immunology and the 2 Laboratory of Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
PURPOSE. Experimental autoimmune uveoretinitis (EAU) is a T-cell–mediated disease induced by immunization with interphotoreceptor retinoid binding protein (IRBP). Major uveitogenic sites have been identified for mice of the H-2r and H-2k haplotypes but not for the H-2b haplotype. The present communication describes the characterization of an epitope contained in residues 1 to 20 of human IRBP that induces EAU in H-2b mice.
METHODS. H-2b (C57BL/6, 129/J) and H-2r (B10.RIII) mice were immunized with peptide 1-20 or with whole (bovine) IRBP. EAU (histopathology) and immunologic responses (delayed-type hypersensitivity [DTH], lymphocyte proliferation, and cytokine production) were assessed after 21 days.
RESULTS. C57BL/6 mice, 129/J and (129/JxC57BL/6)F1 mice, immunized with 200 to
300 µg of peptide, developed DTH and EAU with scores comparable to
those induced by 100 µg IRBP. Their lymphocytes proliferated to the
peptide and produced interferon-
(but not interleukin-4) and
transferred EAU to syngeneic recipients. Lymphocytes of IRBP-immunized
mice also responded to the peptide. Peptide 1-20–immunized B10.RIII
mice failed to develop either disease or immunologic responses.
CONCLUSIONS. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype, which is apparently not presented by the H-2r haplotype.
This article has been cited by other articles:
|
|
 |
|
  S. Sugita, S. Horie, O. Nakamura, Y. Futagami, H. Takase, H. Keino, H. Aburatani, N. Katunuma, K. Ishidoh, Y. Yamamoto, et al. Retinal Pigment Epithelium-Derived CTLA-2{alpha} Induces TGF{beta}-Producing T Regulatory Cells J. Immunol., December 1, 2008; 181(11): 7525 - 7536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. E. Raveney, D. A. Copland, L. B. Nicholson, and A. D. Dick Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease Arch Ophthalmol, October 1, 2008; 126(10): 1390 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Cortes, M. J. Mattapallil, P. B. Silver, L. A. Donoso, G. I. Liou, W. Zhu, C.-C. Chan, and R. R. Caspi Repertoire Analysis and New Pathogenic Epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) Mice Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1946 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Luger, P. B. Silver, J. Tang, D. Cua, Z. Chen, Y. Iwakura, E. P. Bowman, N. M. Sgambellone, C.-C. Chan, and R. R. Caspi Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category J. Exp. Med., April 14, 2008; 205(4): 799 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshimura, K.-H. Sonoda, Y. Miyazaki, Y. Iwakura, T. Ishibashi, A. Yoshimura, and H. Yoshida Differential roles for IFN-{gamma} and IL-17 in experimental autoimmune uveoretinitis Int. Immunol., February 1, 2008; 20(2): 209 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Peng, G. Han, H. Shao, Y. Wang, H. J. Kaplan, and D. Sun Characterization of IL-17+ Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4153 - 4161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Copland, C. J. Calder, B. J.E. Raveney, L. B. Nicholson, J. Phillips, H. Cherwinski, M. Jenmalm, J. D. Sedgwick, and A. D. Dick Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis Am. J. Pathol., August 1, 2007; 171(2): 580 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hisatomi, K.-h. Sonoda, F. Ishikawa, H. Qiao, T. Nakazawa, M. Fukata, T. Nakamura, K. Noda, S. Miyahara, M. Harada, et al. Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation Br. J. Ophthalmol., April 1, 2007; 91(4): 520 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Sonoda, T. Yoshimura, A. Takeda, T. Ishibashi, S. Hamano, and H. Yoshida WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis Int. Immunol., January 1, 2007; 19(1): 93 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Keino, M Takeuchi, Y Usui, T Hattori, N Yamakawa, T Kezuka, J-I Sakai, and M Usui Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis Br. J. Ophthalmol., January 1, 2007; 91(1): 105 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wang, F. Bai, M. Pries, S. Buus, J. U. Prause, and M. H. Nissen Identification of MHC class I h-2 kb/db-restricted immunogenic peptides derived from retinal proteins. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 3939 - 3945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-R. Jiang, L. Hwenda, K. Makinen, C. Oetke, P. R. Crocker, and J. V. Forrester Sialoadhesin Promotes the Inflammatory Response in Experimental Autoimmune Uveoretinitis J. Immunol., August 15, 2006; 177(4): 2258 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Guyver, D. A. Copland, C. J. Calder, A. Sette, J. Sidney, A. D. Dick, and L. B. Nicholson Mapping Immune Responses to mRBP-3 1-16 Peptide with Altered Peptide Ligands Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 2027 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Calder, L. B. Nicholson, and A. D. Dick A Selective Role for the TNF p55 Receptor in Autocrine Signaling following IFN-{gamma} Stimulation in Experimental Autoimmune Uveoretinitis J. Immunol., November 15, 2005; 175(10): 6286 - 6293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hashida, N. Ohguro, K. Nakai, M. Kobashi-Hashida, S.-i. Hashimoto, K. Matsushima, and Y. Tano Microarray Analysis of Cytokine and Chemokine Gene Expression after Prednisolone Treatment in Murine Experimental Autoimmune Uveoretinitis Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4224 - 4234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shao, Y. Peng, T. Liao, M. Wang, M. Song, H. J. Kaplan, and D. Sun A Shared Epitope of the Interphotoreceptor Retinoid-Binding Protein Recognized by the CD4+ and CD8+ Autoreactive T Cells J. Immunol., August 1, 2005; 175(3): 1851 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Bagenstose, R. K. Agarwal, P. B. Silver, D. M. Harlan, S. C. Hoffmann, R. L. Kampen, C.-C. Chan, and R. R. Caspi Disruption of CD40/CD40-Ligand Interactions in a Retinal Autoimmunity Model Results in Protection without Tolerance J. Immunol., July 1, 2005; 175(1): 124 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. M. Z. Howard, H. F. Dong, S. B. Su, R. R. Caspi, X. Chen, P. Plotz, and J. J. Oppenheim Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate Blood, June 1, 2005; 105(11): 4207 - 4214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kitaichi, K. Namba, and A. W. Taylor Inducible immune regulation following autoimmune disease in the immune-privileged eye J. Leukoc. Biol., April 1, 2005; 77(4): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zamiri, S. Masli, N. Kitaichi, A. W. Taylor, and J. W. Streilein Thrombospondin Plays a Vital Role in the Immune Privilege of the Eye Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 908 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Taylor, K. McConnachie, C. Calder, R. Dawson, A. Dick, J. D. Sedgwick, and J. Liversidge Enhanced Tolerance to Autoimmune Uveitis in CD200-Deficient Mice Correlates with a Pronounced Th2 Switch in Response to Antigen Challenge J. Immunol., January 1, 2005; 174(1): 143 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Keino, T. Kezuka, M. Takeuchi, N. Yamakawa, T. Hattori, and M. Usui Prevention of Experimental Autoimmune Uveoretinitis by Vasoactive Intestinal Peptide Arch Ophthalmol, August 1, 2004; 122(8): 1179 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kezuka, M. Takeuchi, H. Keino, Y. Usui, A. Takeuchi, N. Yamakawa, and M. Usui Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune Uveoretinitis via IL-10 J. Immunol., July 15, 2004; 173(2): 1454 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Avichezer, R. S. Grajewski, C.-C. Chan, M. J. Mattapallil, P. B. Silver, J. A. Raber, G. I. Liou, B. Wiggert, G. M. Lewis, L. A. Donoso, et al. An Immunologically Privileged Retinal Antigen Elicits Tolerance: Major Role for Central Selection Mechanisms J. Exp. Med., December 1, 2003; 198(11): 1665 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Sonoda, Y. Sasa, H. Qiao, C. Tsutsumi, T. Hisatomi, S. Komiyama, T. Kubota, T. Sakamoto, Y.-I. Kawano, and T. Ishibashi Immunoregulatory Role of Ocular Macrophages: The Macrophages Produce RANTES to Suppress Experimental Autoimmune Uveitis J. Immunol., September 1, 2003; 171(5): 2652 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Taylor and D. G. Yee Somatostatin Is an Immunosuppressive Factor in Aqueous Humor Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2644 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kitaichi, S. Kotake, T. Morohashi, K. Onoe, S. Ohno, and A. W. Taylor Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells J. Leukoc. Biol., December 1, 2002; 72(6): 1117 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Broderick, R. M. Hoek, J. V. Forrester, J. Liversidge, J. D. Sedgwick, and A. D. Dick Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis Am. J. Pathol., November 1, 2002; 161(5): 1669 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Dick, C. Broderick, J. V. Forrester, and G. J. Wright Distribution of OX2 Antigen and OX2 Receptor within Retina Invest. Ophthalmol. Vis. Sci., January 1, 2001; 42(1): 170 - 176. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
