| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 From the University Medical Centre Utrecht, Department of Ophthalmology, The Netherlands; and the 2 TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
PURPOSE. Macular pigment (MP) may protect against age-related macular degeneration. This study was conducted to determine the extent of changes in the macular pigment density as a consequence of oral supplementation with lutein. A second purpose was to compare two objective measurement techniques.
METHODS. In the first technique, reflectance maps were made with a scanning laser ophthalmoscope. Digital subtraction of log reflectance maps and comparison between the foveal area and a 14° temporal site provided MP density estimates. In the second technique, spectral fundus reflectance of the fovea was measured with a fundus reflectometer and analyzed with a detailed optical model, to arrive at MP density values. Eight subjects participated in this study. They took 10 mg lutein per day for 12 weeks. Plasma lutein concentration was measured at 4-week intervals.
RESULTS. After 4 weeks, mean blood level of lutein had increased from 0.18 to 0.90 µM. It stayed at this level throughout the intake period and declined to 0.28 µM 4 weeks after termination. Measurement of the density of MP showed a within-subject variation of 10% with MP maps and 17% with spectral reflectance analysis. MP density showed a mean linear 4-week increase of 5.3% (P < 0.001) and 4.1% (P = 0.022), respectively.
CONCLUSIONS. Supplementation with lutein significantly increased the density of the MP. Analyzing reflectance maps with a scanning laser ophthalmoscope provided very reliable estimates of MP.
This article has been cited by other articles:
|
|
 |
|
  J. van de Kraats, M. J. Kanis, S. W. Genders, and D. van Norren Lutein and Zeaxanthin Measured Separately in the Living Human Retina with Fundus Reflectometry Invest. Ophthalmol. Vis. Sci., December 1, 2008; 49(12): 5568 - 5573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhao and B. V. Sweet Lutein and zeaxanthin for macular degeneration Am. J. Health Syst. Pharm., July 1, 2008; 65(13): 1232 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J Johnson, H.-Y. Chung, S. M Caldarella, and D M. Snodderly The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1521 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. K. Wolf-Schnurrbusch, N. Roosli, E. Weyermann, M. R. Heldner, K. Hohne, and S. Wolf Ethnic Differences in Macular Pigment Density and Distribution Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3783 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iannaccone, M. Mura, K. T. Gallaher, E. J. Johnson, W. A. Todd, E. Kenyon, T. L. Harris, T. Harris, S. Satterfield, K. C. Johnson, et al. Macular Pigment Optical Density in the Elderly: Findings in a Large Biracial Midsouth Population Sample Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bhosale, D. Y. Zhao, and P. S. Bernstein HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 543 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rosenthal, J. Kim, F. de Monastario, D. J. S. Thompson, R. A. Bone, J. T. Landrum, F. F. de Moura, F. Khachik, H. Chen, R. L. Schleicher, et al. Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or Older Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5227 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Khachik, E. London, F. F. de Moura, M. Johnson, S. Steidl, L. DeTolla, S. Shipley, R. Sanchez, X.-Q. Chen, J. Flaws, et al. Chronic Ingestion of (3R,3'R,6'R)-Lutein and (3R,3'R)-Zeaxanthin in the Female Rhesus Macaque Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5476 - 5486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R Trumbo and K. C Ellwood Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 971 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Mares, T. L LaRowe, D M. Snodderly, S. M Moeller, M. J Gruber, M. L Klein, B. R Wooten, E. J Johnson, R. J Chappell, and for the CAREDS Macular Pigment Study Group and Inv Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1107 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Whitehead, J. A. Mares, and R. P. Danis Macular Pigment: A Review of Current Knowledge Arch Ophthalmol, July 1, 2006; 124(7): 1038 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot and D. van Norren Macular Pigment Shows Ringlike Structures Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Neuringer, M. M. Sandstrom, E. J. Johnson, and D. M. Snodderly Nutritional Manipulation of Primate Retinas, I: Effects of Lutein or Zeaxanthin Supplements on Serum and Macular Pigment in Xanthophyll-Free Rhesus Monkeys Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3234 - 3243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y.-F. Leung, M. M. Sandstrom, C. L. Zucker, M. Neuringer, and D. M. Snodderly Nutritional Manipulation of Primate Retinas, II: Effects of Age, n-3 Fatty Acids, Lutein, and Zeaxanthin on Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3244 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L Molldrem, J. Li, P. W Simon, and S. A Tanumihardjo Lutein and {beta}-carotene from lutein-containing yellow carrots are bioavailable in humans Am. J. Clinical Nutrition, July 1, 2004; 80(1): 131 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Snodderly, J. A. Mares, B. R. Wooten, L. Oxton, M. Gruber, and T. Ficek Macular Pigment Measurement by Heterochromatic Flicker Photometry in Older Subjects: The Carotenoids and Age-Related Eye Disease Study Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Nelson, P. S. Bernstein, M. C. Schmidt, M. S. Von Tress, and E. W. Askew Dietary Modification and Moderate Antioxidant Supplementation Differentially Affect Serum Carotenoids, Antioxidant Levels and Markers of Oxidative Stress in Older Humans J. Nutr., October 1, 2003; 133(10): 3117 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Gale, N. F. Hall, D. I. W. Phillips, and C. N. Martyn Lutein and Zeaxanthin Status and Risk of Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2461 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, J. A. Weststrate, L. B. M. Tijburg, G. van Poppel, A. A. Vink, T. T.J.M Berendschot, M. L. Bots, W. A. M. Castenmiller, and A. F. M. Kardinaal Decreased Carotenoid Concentrations Due to Dietary Sucrose Polyesters Do Not Affect Possible Markers of Disease Risk in Humans J. Nutr., March 1, 2003; 133(3): 720 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Wenzel, K. Fuld, and J. M. Stringham Light Exposure and Macular Pigment Optical Density Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 306 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Heinrich, C. Gartner, M. Wiebusch, O. Eichler, H. Sies, H. Tronnier, and W. Stahl Supplementation with {beta}-Carotene or a Similar Amount of Mixed Carotenoids Protects Humans from UV-Induced Erythema J. Nutr., January 1, 2003; 133(1): 98 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot, W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, A. F. M. Kardinaal, G. van Poppel, and D. van Norren Lens Aging in Relation to Nutritional Determinants and Possible Risk Factors for Age-Related Cataract Arch Ophthalmol, December 1, 2002; 120(12): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Bowen, S. M. Herbst-Espinosa, E. A. Hussain, and M. Stacewicz-Sapuntzakis Esterification Does Not Impair Lutein Bioavailability in Humans J. Nutr., December 1, 2002; 132(12): 3668 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Broekmans, T. T. Berendschot, I. A. Klopping-Ketelaars, A. J de Vries, R A. Goldbohm, L. B. Tijburg, A. F. Kardinaal, and G. van Poppel Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin Am. J. Clinical Nutrition, September 1, 2002; 76(3): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot, J. J. M. Willemse-Assink, M. Bastiaanse, P. T. V. M. de Jong, and D. van Norren Macular Pigment and Melanin in Age-Related Maculopathy in a General Population Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1928 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Bour, L. Koo, F. C. Delori, P. Apkarian, and A. B. Fulton Fundus Photography for Measurement of Macular Pigment Density Distribution in Children Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1450 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Toyoda, L. R. Thomson, A. Langner, N. E. Craft, K. M. Garnett, C. R. Nichols, K. M. Cheng, and C. K. Dorey Effect of Dietary Zeaxanthin on Tissue Distribution of Zeaxanthin and Lutein in Quail Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1210 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Curran Celentano, J. D. Burke, and B. R. Hammond Jr. In Vivo Assessment of Retinal Carotenoids: Macular Pigment Detection Techniques and Their Impact on Monitoring Pigment Status J. Nutr., March 1, 2002; 132(3): 535S - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Krinsky Possible Biologic Mechanisms for a Protective Role of Xanthophylls J. Nutr., March 1, 2002; 132(3): 540S - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Aleman, J. L. Duncan, M. L. Bieber, E. de Castro, D. A. Marks, L. M. Gardner, J. D. Steinberg, A. V. Cideciyan, M. G. Maguire, and S. G. Jacobson Macular Pigment and Lutein Supplementation in Retinitis Pigmentosa and Usher Syndrome Invest. Ophthalmol. Vis. Sci., July 1, 2001; 42(8): 1873 - 1881. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
