IOVS Microbiology and Molecular Biology Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maddess, T.
Right arrow Articles by Dobinson, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maddess, T.
Right arrow Articles by Dobinson, J.
(Investigative Ophthalmology and Visual Science. 2000;41:3818-3826.)
© 2000 by The Association for Research in Vision and Ophthalmology, Inc.

A Spatial Frequency-Doubling Illusion-Based Pattern Electroretinogram for Glaucoma

Teddy Maddess1, Andrew Charles James1, Ivan Goldberg2, Stephen Wine2 and Jeffrey Dobinson2

1 From the Centre for Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra; and the 2 Prince of Wales Hospital, Sydney, Australia.

PURPOSE. A pattern electroretinogram (PERG) in which stimuli displaying the frequency-doubling (FD) illusion are presented simultaneously to multiple parts of the visual field was evaluated for its ability to diagnose glaucoma. This multiregion FD PERG is referred to in the current study as the MFP.

METHODS. The nine stimulus regions were temporally modulated at incommensurate frequencies typically producing an FD percept. Two other spatial scales of the stimuli were also investigated. The sensitivity and specificity of MFP were examined using linear and quadratic discriminant methods.

RESULTS. Even with the simpler linear discriminant classification, sensitivities and specificities of 100% were obtained in eyes with moderate to severe glaucoma. Of eyes with glaucoma strongly suspected, 67% were classified as being glaucomatous. Stimulus patterns having differing spatial scales produced different PERG visual field dependencies.

CONCLUSIONS. The differing results for the 16-fold change in spatial scale may reflect the accessing of different mechanisms. The MFP method appears to have significant value for the diagnosis of glaucoma.




This article has been cited by other articles:


Home page
 IOVSHome page
T. Maddess, A. C. James, I. Goldberg, S. Wine, and J. Dobinson
Comparing a Parallel PERG, Automated Perimetry, and Frequency-Doubling Thresholds
Invest. Ophthalmol. Vis. Sci., November 1, 2000; 41(12): 3827 - 3832.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Association for Research in Vision and Ophthalmology