| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth.
PURPOSE. To measure the intraretinal oxygen environment at different stages in the Royal College of Surgeons (RCS) rat model of retinal degeneration to determine whether changes in oxygen level are an important aspect of the disease.
METHODS. Oxygen-sensitive microelectrodes were used to measure oxygen tension as a function of depth through the retina of anesthetized, mechanically ventilated RCS rats at ages ranging from postnatal day (P)20 to P104. The oxygen profiles were correlated with histologic observations of the cellular changes within the dystrophic retinas and compared with those in RCS-rdy+ control animals and published values in normal mature rats.
RESULTS. Although the youngest rats studied exhibited some differences in intraretinal oxygen distribution compared with mature animals, the distribution in dystrophic RCS rats at P20 was not significantly different from that in age-matched control subjects. However, the intraretinal oxygen distribution in dystrophic RCS rats was clearly affected after approximately P30, reflecting a loss of photoreceptor oxygen consumption consistent with histologic observations. In contrast, oxygen uptake by the inner retina was still evident long after the loss of photoreceptors was essentially complete.
CONCLUSIONS. There was no significant tissue hypoxia during photoreceptor degeneration in the dystrophic RCS rat. The changes in intraretinal oxygen distribution are consistent with the loss of outer retinal oxygen uptake but the preservation of inner retinal oxygen metabolism.
This article has been cited by other articles:
|
|
 |
|
  R. Natoli, J. Provis, K. Valter, and J. Stone Expression and Role of the Early-Response Gene Oxr1 in the Hyperoxia-Challenged Mouse Retina Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4561 - 4567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chrysostomou, J. Stone, S. Stowe, N. L. Barnett, and K. Valter The Status of Cones in the Rhodopsin Mutant P23H-3 Retina: Light-Regulated Damage and Repair in Parallel with Rods Invest. Ophthalmol. Vis. Sci., March 1, 2008; 49(3): 1116 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yi, R. E. I. Nakamura, O. Mohamed, D. Dufort, and A. S. Hackam Characterization of Wnt Signaling during Photoreceptor Degeneration Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5733 - 5741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Smit-McBride, S. L. Oltjen, M. M. LaVail, and L. M. Hjelmeland A Strong Genetic Determinant of Hyperoxia-Related Retinal Degeneration on Mouse Chromosome 6 Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 405 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. de Gooyer, K. A. Stevenson, P. Humphries, D. A. C. Simpson, T. M. Curtis, T. A. Gardiner, and A. W. Stitt Rod Photoreceptor Loss in Rho-/- Mice Reduces Retinal Hypoxia and Hypoxia-Regulated Gene Expression Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5553 - 5560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. de Gooyer, K. A. Stevenson, P. Humphries, D. A. C. Simpson, T. A. Gardiner, and A. W. Stitt Retinopathy Is Reduced during Experimental Diabetes in a Mouse Model of Outer Retinal Degeneration Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5561 - 5568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cheng, G. Nair, T. A. Walker, M. K. Kim, M. T. Pardue, P. M. Thule, D. E. Olson, and T. Q. Duong Structural and functional MRI reveals multiple retinal layers PNAS, November 14, 2006; 103(46): 17525 - 17530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Cringle, P. K. Yu, E.-N. Su, and D.-Y. Yu Oxygen distribution and consumption in the developing rat retina. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 4072 - 4076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Padnick-Silver, J. J. K. Derwent, E. Giuliano, K. Narfstrom, and R. A. Linsenmeier Retinal oxygenation and oxygen metabolism in abyssinian cats with a hereditary retinal degeneration. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3683 - 3689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Komeima, B. S. Rogers, L. Lu, and P. A. Campochiaro Antioxidants reduce cone cell death in a model of retinitis pigmentosa PNAS, July 25, 2006; 103(30): 11300 - 11305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Y. Yu and S. J. Cringle Oxygen distribution in the mouse retina. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 1109 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Y. Yu, S. Cringle, K. Valter, N. Walsh, D. Lee, and J. Stone Photoreceptor Death, Trophic Factor Expression, Retinal Oxygen Status, and Photoreceptor Function in the P23H Rat Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 2013 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, Y. Ito, E. Berlin, R. Roberts, and B. A. Berkowitz Role of Hypoxia during Normal Retinal Vessel Development and in Experimental Retinopathy of Prematurity Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3119 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Wangsa-Wirawan and R. A. Linsenmeier Retinal Oxygen: Fundamental and Clinical Aspects Arch Ophthalmol, April 1, 2003; 121(4): 547 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Cringle, D.-Y. Yu, P. K. Yu, and E.-N. Su Intraretinal Oxygen Consumption in the Rat In Vivo Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1922 - 1927. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
