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(Investigative Ophthalmology and Visual Science. 2000;41:1681-1683.)
© 2000 by The Association for Research in Vision and Ophthalmology, Inc.

Ascorbic Acid Content of Human Corneal Epithelium

Richard F. Brubaker, William M. Bourne, Lori A. Bachman and Jay W. McLaren

From the Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

PURPOSE. To measure the concentration of ascorbic acid in the human corneal epithelium.

METHODS. Corneal epithelium was removed from postmortem eyes 4 to 16 hours after death and ascorbate measured by high-performance liquid chromatography.

RESULTS. The concentration of ascorbate was 1.33 ± 0.48 mg/gm wet weight (mean ± SD), estimated to be 14 times its concentration in the aqueous humor.

CONCLUSIONS. Ascorbate can protect the basal layer of the epithelium by absorption of incident ultraviolet radiation.




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