HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, X. Articles by MacLeish, P. R. Search for Related Content PubMed PubMed Citation Articles by Chen, X. Articles by MacLeish, P. R.

Cone Properties of Retinal Margin Cells in the Monkey (Macaca mulatta)

¹ From the Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia; and ² Division of Neurobiology, Yale School of Medicine, New Haven, Connecticut.

PURPOSE. To characterize a cell population in the monkey retinal margin that was labeled with a cone-specific antibody and to determine the presence of additional markers.

METHODS. Retinal whole-mount preparations from infant and adult rhesus monkeys (Macaca mulatta) were immunolabeled by incubation overnight with the primary antibodies 7G6, a cone-specific antibody; SV2, a synaptic-vesicle antibody; and opsin antibodies that recognize either the short or long/middle wavelength–sensitive opsins.

RESULTS. The retinal margin cells labeled by 7G6 lay within 1 mm of the ora serrata and differed from 7G6-labeled cones in the central retina. The margin cells possessed a soma, a fiber process, and a terminal enlargement that lay in the plane of the retina; no outer segment was discernible. A total of 5400 and 7252 margin cones cells were found in each of two monkeys. The terminal enlargement and soma of the labeled margin cells also showed SV2 immunoreactivity. Surprisingly, opsin immunoreactivity extended throughout the margin cell, which is consistent with the absence of a discernible outer segment.

CONCLUSIONS. Cells with immunoreactive cone properties were found in the margin of the monkey retina. The absence of an outer segment and the presence of somatic opsin and SV2 are reminiscent of features observed in the central cones of fetal monkey retinas. These results suggest that a subpopulation of cones in the retinal margin might fail to mature completely and thus retain juvenile characteristics into adulthood.

This article has been cited by other articles:

				H. Zhang, N. Cuenca, T. Ivanova, J. Church-Kopish, J. M. Frederick, P. R. MacLeish, and W. Baehr Identification and Light-Dependent Translocation of a Cone-Specific Antigen, Cone Arrestin, Recognized by Monoclonal Antibody 7G6 Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 2858 - 2867. [Abstract] [Full Text] [PDF]

				Q. Liu, J. Zhou, S. P. Daiger, D. B. Farber, J. R. Heckenlively, J. E. Smith, L. S. Sullivan, J. Zuo, A. H. Milam, and E. A. Pierce Identification and Subcellular Localization of the RP1 Protein in Human and Mouse Photoreceptors Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 22 - 32. [Abstract] [Full Text] [PDF]