IOVS BJO
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurks, H. M. H.
Right arrow Articles by Jager, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurks, H. M. H.
Right arrow Articles by Jager, M. J.
(Investigative Ophthalmology and Visual Science. 2000;41:2023-2027.)
© 2000 by The Association for Research in Vision and Ophthalmology, Inc.

Expression of Epidermal Growth Factor Receptor: Risk Factor in Uveal Melanoma

H. Monique H. Hurks1, Jessica A. W. Metzelaar-Blok1, Ed R. Barthen1, Aeilko H. Zwinderman2, Didi De Wolff-Rouendaal1, Jan E. E. Keunen1 and Martine J. Jager1

1 From the Departments of Ophthalmology and 2 Medical Statistics, Leiden University Medical Center, The Netherlands.

PURPOSE. To investigate the prognostic significance of the expression of epidermal growth factor receptor (EGFR) in uveal melanoma. EGFR is a transmembrane glycoprotein, and its expression has been correlated with the development of metastases in various malignancies.

METHODS. Frozen sections from 22 primary uveal melanomas were examined for EGFR expression by a three-step immunoperoxidase staining, using a mouse anti-human EGFR IgG2b monoclonal antibody. The results were compared with patient survival and clinical and histopathologic parameters.

RESULTS. EGFR expression could not be determined on one tumor due to excessive pigmentation. Two patients died of causes unrelated to melanoma, and two patients were lost to follow-up. Out of 21 tumors, six tumors showed immunoreactivity for EGFR. Five of these six patients (83%) died due to metastases, compared with 2 (17%) of 12 patients with no EGFR expression (Kaplan–Meier analysis P = 0.0004). EGFR-positive tumors tended to have a greater tumor prominence and a higher mitotic rate.

CONCLUSIONS. The expression of EGFR was significantly correlated with death due to metastatic disease and therefore can be regarded as an important prognostic factor in human uveal melanoma.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
R. Schuster, N. E. Bechrakis, A. Stroux, A. Busse, A. Schmittel, C. Scheibenbogen, E. Thiel, M. H. Foerster, and U. Keilholz
Circulating Tumor Cells as Prognostic Factor for Distant Metastases and Survival in Patients with Primary Uveal Melanoma
Clin. Cancer Res., February 15, 2007; 13(4): 1171 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. K. L. Woodward, S. R. Elshaw, A. K. Murray, C. E. Nichols, N. Cross, D. Laws, I. G. Rennie, and K. Sisley
Stimulation and Inhibition of Uveal Melanoma Invasion by HGF, GRO, IL-1{alpha} and TGF-{beta}
Invest. Ophthalmol. Vis. Sci., October 1, 2002; 43(10): 3144 - 3152.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. All-Ericsson, L. Girnita, S. Seregard, A. Bartolazzi, M. J. Jager, and O. Larsson
Insulin-like Growth Factor-1 Receptor in Uveal Melanoma: A Predictor for Metastatic Disease and a Potential Therapeutic Target
Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 1 - 8.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Association for Research in Vision and Ophthalmology