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(Investigative Ophthalmology and Visual Science. 2000;41:2067-2069.)
© 2000 by The Association for Research in Vision and Ophthalmology, Inc.

UV Absorption by Uric Acid in Diurnal Bird Aqueous Humor

Amund Ringvold1, Erlend Anderssen2 and Inge Kjønniksen2

1 From the Eye Department and 2 The National Hospital Pharmacy, National Hospital, Oslo, Norway.

PURPOSE. To analyze the components responsible for the UV absorbance in diurnal bird aqueous humor.

METHODS. The absorbance studies were carried out using a Hitachi spectrophotometer (U 2000). Uric acid was determined by high-performance liquid chromatography (LC-10 system; Shimadzu, Kyoto, Japan). Chicken and turkey eyes were examined.

RESULTS. The UV absorbance in chicken aqueous was largely accounted for by the presence of protein, tryptophan, tyrosine, ascorbic acid, and uric acid. Ascorbic acid was low (23 µmol/l). Uric acid was, on the other hand, remarkably high (151 µmol/l) compared with that in mammals (cattle, 16 µmol/l). Principally the same results were obtained in chicken and turkey.

CONCLUSIONS. Uric acid is a significant UV-absorbing substance in the aqueous humor of diurnal birds with its peak absorbance at 292 nm. The hypothesis that the aqueous humor acts as a UV filter seems to be valid also for the avian eye. However, in these eyes uric acid fulfills the role that ascorbic acid does in mammals.






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