| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Biological Sciences, Allergan Inc., Irvine, California.
PURPOSE. To characterize, using both conventional and multifocal electroretinogram (ERG) recordings as well as histologic measures, retinal injury in the chronic ocular hypertensive primate model for experimental glaucoma.
METHODS. Ocular hypertension was induced in the right eye of 7 cynomolgous monkeys, Macaca fascicularis, using laser injury to the aqueous outflow tissue at the anterior chamber angle. At 16 months after IOP elevation, ERG recordings were made from both eyes of all animals using both conventional and multifocal methods. After electrophysiological recording, animals were killed and retinal samples were radially sectioned for histologic analysis.
RESULTS. Histologic measures showed that ocular hypertensive injury was largely or completely limited to a loss of retinal ganglion cells (RGCs). The degree of RGC loss was similar in central and peripheral retina. Amplitudes of conventional ERG responses were mostly unaffected in eyes having severe loss of RGCs, a finding that is consistent with limited injury to photoreceptors, bipolar cells, and amacrine cells. Peaks in both the first- and second-order multifocal ERG responses were attenuated in ocular hypertensive eyes, and amplitude of these peaks was highly correlated with the density of surviving RGCs.
CONCLUSIONS. The results are consistent with a conclusion that both first- and second-order components of the multifocal ERG response from the monkey reflect a significant contribution from activity in RGCs and may provide a useful measure for the clinical diagnosis and management of glaucoma.
This article has been cited by other articles:
|
|
 |
|
  N. V. Rangaswamy, S. Shirato, M. Kaneko, B. I. Digby, J. G. Robson, and L. J. Frishman Effects of Spectral Characteristics of Ganzfeld Stimuli on the Photopic Negative Response (PhNR) of the ERG Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4818 - 4828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Rangaswamy, W. Zhou, R. S. Harwerth, and L. J. Frishman Effect of Experimental Glaucoma in Primates on Oscillatory Potentials of the Slow-Sequence mfERG Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 753 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Lalonde, B. C. Chauhan, and F. Tremblay Retinal ganglion cell activity from the multifocal electroretinogram in pig: optic nerve section, anaesthesia and intravitreal tetrodotoxin J. Physiol., January 15, 2006; 570(2): 325 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Hare, E. WoldeMussie, R. K. Lai, H. Ton, G. Ruiz, T. Chun, and L. Wheeler Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, I: Functional Measures Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2625 - 2639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Hare, E. WoldeMussie, R. N. Weinreb, H. Ton, G. Ruiz, M. Wijono, B. Feldmann, L. Zangwill, and L. Wheeler Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, II: Structural Measures Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2640 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fortune, L. Wang, B. V. Bui, G. Cull, J. Dong, and G. A. Cioffi Local Ganglion Cell Contributions to the Macaque Electroretinogram Revealed by Experimental Nerve Fiber Layer Bundle Defect Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4567 - 4579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Raz, I. Perlman, C. L. Percicot, G. N. Lambrou, and R. Ofri Functional Damage to Inner and Outer Retinal Cells in Experimental Glaucoma Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3675 - 3684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Chauhan, J. Pan, M. L. Archibald, T. L. LeVatte, M. E. M. Kelly, and F. Tremblay Effect of Intraocular Pressure on Optic Disc Topography, Electroretinography, and Axonal Loss in a Chronic Pressure-Induced Rat Model of Optic Nerve Damage Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 2969 - 2976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fortune, M. A. Bearse Jr, G. A. Cioffi, and C. A. Johnson Selective Loss of an Oscillatory Component from Temporal Retinal Multifocal ERG Responses in Glaucoma Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2638 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Raz, M. W. Seeliger, A. B. Geva, C. L. Percicot, G. N. Lambrou, and R. Ofri The Effect of Contrast and Luminance on mfERG Responses in a Monkey Model of Glaucoma Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 2027 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Hood, L. J. Frishman, S. Saszik, and S. Viswanathan Retinal Origins of the Primate Multifocal ERG: Implications for the Human Response Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1673 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Quigley, T. M. Nork, G. L. Poulsen, R. W. Nickells, J. N. Ver Hoeve, N.-C. Cho, L. A. Levin, and M. J. Lucarelli Selective Citation of Evidence Regarding Photoreceptor Loss in Glaucoma Arch Ophthalmol, September 1, 2001; 119(9): 1390 - 1391. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
