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Long-term Fluctuation in Short-Wavelength Automated Perimetry in Glaucoma Suspects and Glaucoma Patients

¹ From the School of Optometry, University of Waterloo, Ontario, Canada; ² School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; ³ University Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, United Kingdom; ⁴ Department of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom; and ⁵ Department of Ophthalmology, Faculty of Medicine, University of Toronto, Ontario, Canada.

PURPOSE. To determine the magnitude of the homogenous, LF(Ho), and the heterogeneous, LF(He), components of the long-term fluctuation (LF) in glaucoma suspects and in stable primary open angle glaucoma (POAG) patients undergoing short-wavelength automated perimetry (SWAP) and to compare the magnitude of the SWAP LF components with those elicited by standard white-on-white (W-W) perimetry.

METHODS. The sample comprised 33 glaucoma suspects and 17 patients with early-to-moderate stable POAG who underwent W-W perimetry and SWAP at each of six visits over a mean period of 12.75 months (SD, 2.29). The LF(Ho), LF(He), and error components of the long-term fluctuation were determined between the third and seventh visual field examinations. The intervening visual field examinations and the optic nerve head parameters, derived both by stereo observation and by the Heidelberg Retinal Tomograph, were used to confirm stability over the follow-up period.

RESULTS. The LF(Ho) and LF(He) components were larger in the POAG patients than in the glaucoma suspects for both W-W perimetry and SWAP; the magnitude was independent of the depth of defect and of the short-term fluctuation. All three components of long-term fluctuation were greater for SWAP than for W-W perimetry, both in the glaucoma suspects and in the POAG patients.

CONCLUSIONS. SWAP exhibits greater long-term fluctuation than white-on-white perimetry. The usefulness of SWAP will be limited if the extent of this variability is not overcome in future statistical procedures developed to detect progressive visual field loss.

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