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(Investigative Ophthalmology and Visual Science. 2001;42:318-320.)
© 2001 by The Association for Research in Vision and Ophthalmology, Inc.

Group II PLA2 Content of Tears in Normal Subjects

K. Matti Saari1, Valtteri V. Aho1, Ville Paavilainen1 and Timo J. Nevalainen2

1 From the Departments of Ophthalmology and 2 Pathology, University of Turku, Turku, Finland.

PURPOSE. To determine the concentration of group II phospholipase (PL) A2, an antimicrobial molecule, in tears of normal subjects in different age and sex groups.

METHODS. PLA2 content of tears was measured in 122 healthy volunteers with ages ranging from 20 to 89 years (mean, 49.5 years) by a time-resolved fluoroimmunoassay using a polyclonal rabbit antibody to recombinant human PLA2.

RESULTS. The mean concentration of PLA2 in tears was 54.5 ± 33.9 µg/ml. It was highest in the age group 20 to 29 years (81.6 ± 32.0 µg/ml), and a decrease of concentration occurred with an increase of age. PLA2 values were statistically significantly lower in the age group 60 to 69 years (P = 0.0013) and 70 years or more (P = 0.0001) than in the age group 20 to 29 years. There were no statistically significant differences in PLA2 content of tears between the genders in any age group (P = 0.798).

CONCLUSIONS. The results indicate that tears contain a high concentration of PLA2 and that PLA2 levels decrease with an increase of age and/or reflex tear component of the sample analyzed.




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