| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 From the University Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester; the 2 Visual Sciences Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester; and the 3 Department of Optometry and Vision Sciences, Cardiff University, United Kingdom.
PURPOSE. Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European population.
METHODS. The optical density of MP was measured psychophysically in 46 subjects ranging in age from 21 to 81 years with healthy maculae and in 9 healthy eyes known to be at high-risk of AMD because of advanced disease in the fellow eye. Each eye in the latter group was matched with a control eye on the basis of variables believed to be associated with the optical density of MP (iris color, gender, smoking habits, age, and lens density).
RESULTS. There was an age-related decline in the optical density of macular pigment among volunteers with no ocular disease (right eye: r2 = 0.29, P = 0.0006; left eye: r2 = 0.29, P < 0.0001). Healthy eyes predisposed to AMD had significantly less MP than healthy eyes at no such risk (Wilcoxon’s signed rank test: P = 0.015).
CONCLUSIONS. The two most important risk factors for AMD are associated with a relative absence of MP. These findings are consistent with the hypothesis that supplemental lutein and zeaxanthin may delay, avert, or modify the course of this disease.
This article has been cited by other articles:
|
|
 |
|
  M. J. Kanis, R. P. L. Wisse, T. T. J. M. Berendschot, J. van de Kraats, and D. van Norren Foveal Cone-Photoreceptor Integrity in Aging Macula Disorder Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2077 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schmitz-Valckenberg, K. Fan, A. Nugent, G. S. Rubin, T. Peto, A. Tufail, C. Egan, A. C. Bird, and F. W. Fitzke Correlation of Functional Impairment and Morphological Alterations in Patients With Group 2A Idiopathic Juxtafoveal Retinal Telangiectasia Arch Ophthalmol, March 1, 2008; 126(3): 330 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S H M. Liew, C. E Gilbert, T. D Spector, J. Marshall, and C. J Hammond The role of heredity in determining central retinal thickness Br. J. Ophthalmol., September 1, 2007; 91(9): 1143 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. K. Wolf-Schnurrbusch, N. Roosli, E. Weyermann, M. R. Heldner, K. Hohne, and S. Wolf Ethnic Differences in Macular Pigment Density and Distribution Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3783 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iannaccone, M. Mura, K. T. Gallaher, E. J. Johnson, W. A. Todd, E. Kenyon, T. L. Harris, T. Harris, S. Satterfield, K. C. Johnson, et al. Macular Pigment Optical Density in the Elderly: Findings in a Large Biracial Midsouth Population Sample Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R E Hogg, R S Anderson, M R Stevenson, M B Zlatkova, and U Chakravarthy In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry Br. J. Ophthalmol., April 1, 2007; 91(4): 485 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R Trumbo and K. C Ellwood Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 971 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Moeller, N. Parekh, L. Tinker, C. Ritenbaugh, B. Blodi, R. B. Wallace, J. A. Mares, and for the CAREDS Research Study Group Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS): Ancillary Study of the Women's Health Initiative. Arch Ophthalmol, August 1, 2006; 124(8): 1151 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Whitehead, J. A. Mares, and R. P. Danis Macular Pigment: A Review of Current Knowledge Arch Ophthalmol, July 1, 2006; 124(7): 1038 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delcourt, I. Carriere, M. Delage, P. Barberger-Gateau, W. Schalch, and the POLA Study Group Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study. Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2329 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot and D. van Norren Macular Pigment Shows Ringlike Structures Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. M. Liew, C. E. Gilbert, T. D. Spector, J. Mellerio, J. Marshall, F. J. van Kuijk, S. Beatty, F. Fitzke, and C. J. Hammond Heritability of Macular Pigment: A Twin Study Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4430 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Strauss The Retinal Pigment Epithelium in Visual Function Physiol Rev, July 1, 2005; 85(3): 845 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Burke, J. Curran-Celentano, and A. J. Wenzel Diet and Serum Carotenoid Concentrations Affect Macular Pigment Optical Density in Adults 45 Years and Older J. Nutr., May 1, 2005; 135(5): 1208 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Neelam, N. O'Gorman, J. Nolan, O. O'Donovan, H. B. Wong, K. G. A. Eong, and S. Beatty Measurement of Macular Pigment: Raman Spectroscopy versus Heterochromatic Flicker Photometry Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 1023 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Johnson, M. Neuringer, R. M. Russell, W. Schalch, and D. M. Snodderly Nutritional Manipulation of Primate Retinas, III: Effects of Lutein or Zeaxanthin Supplementation on Adipose Tissue and Retina of Xanthophyll-Free Monkeys Invest. Ophthalmol. Vis. Sci., February 1, 2005; 46(2): 692 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nolan, O. O'Donovan, H. Kavanagh, J. Stack, M. Harrison, A. Muldoon, J. Mellerio, and S. Beatty Macular Pigment and Percentage of Body Fat Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3940 - 3950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Neuringer, M. M. Sandstrom, E. J. Johnson, and D. M. Snodderly Nutritional Manipulation of Primate Retinas, I: Effects of Lutein or Zeaxanthin Supplements on Serum and Macular Pigment in Xanthophyll-Free Rhesus Monkeys Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3234 - 3243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Chung, H. M. Rasmussen, and E. J. Johnson Lutein Bioavailability Is Higher from Lutein-Enriched Eggs than from Supplements and Spinach in Men J. Nutr., August 1, 2004; 134(8): 1887 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L Molldrem, J. Li, P. W Simon, and S. A Tanumihardjo Lutein and {beta}-carotene from lutein-containing yellow carrots are bioavailable in humans Am. J. Clinical Nutrition, July 1, 2004; 80(1): 131 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, J. M. Seddon, B. Rosner, W. C. Willett, and S. E. Hankinson Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoids and Risk of Age-Related Maculopathy Arch Ophthalmol, June 1, 2004; 122(6): 883 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Zarbin Current Concepts in the Pathogenesis of Age-Related Macular Degeneration Arch Ophthalmol, April 1, 2004; 122(4): 598 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Snodderly, J. A. Mares, B. R. Wooten, L. Oxton, M. Gruber, and T. Ficek Macular Pigment Measurement by Heterochromatic Flicker Photometry in Older Subjects: The Carotenoids and Age-Related Eye Disease Study Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Herron and M. L. Fernandez Are the Current Dietary Guidelines Regarding Egg Consumption Appropriate? J. Nutr., January 1, 2004; 134(1): 187 - 190. [Full Text] [PDF]
|
|
|
|
|
|
D.-Y. Zhao, S. W. Wintch, I. V. Ermakov, W. Gellermann, and P. S. Bernstein Resonance Raman Measurement of Macular Carotenoids in Retinal, Choroidal, and Macular Dystrophies Arch Ophthalmol, July 1, 2003; 121(7): 967 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fernandes, D. V. Bradley, M. Tigges, J. Tigges, and J. G. Herndon Ocular Measurements throughout the Adult Life Span of Rhesus Monkeys Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2373 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Gale, N. F. Hall, D. I. W. Phillips, and C. N. Martyn Lutein and Zeaxanthin Status and Risk of Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2461 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Bowen, S. M. Herbst-Espinosa, E. A. Hussain, and M. Stacewicz-Sapuntzakis Esterification Does Not Impair Lutein Bioavailability in Humans J. Nutr., December 1, 2002; 132(12): 3668 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Thomson, Y. Toyoda, A. Langner, F. C. Delori, K. M. Garnett, N. Craft, C. R. Nichols, K. M. Cheng, and C. K. Dorey Elevated Retinal Zeaxanthin and Prevention of Light-Induced Photoreceptor Cell Death in Quail Invest. Ophthalmol. Vis. Sci., November 1, 2002; 43(11): 3538 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot, J. J. M. Willemse-Assink, M. Bastiaanse, P. T. V. M. de Jong, and D. van Norren Macular Pigment and Melanin in Age-Related Maculopathy in a General Population Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1928 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Toyoda, L. R. Thomson, A. Langner, N. E. Craft, K. M. Garnett, C. R. Nichols, K. M. Cheng, and C. K. Dorey Effect of Dietary Zeaxanthin on Tissue Distribution of Zeaxanthin and Lutein in Quail Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1210 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Curran Celentano, J. D. Burke, and B. R. Hammond Jr. In Vivo Assessment of Retinal Carotenoids: Macular Pigment Detection Techniques and Their Impact on Monitoring Pigment Status J. Nutr., March 1, 2002; 132(3): 535S - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. Davies and A. B. Morland Color Matching in Diabetes: Optical Density of the Crystalline Lens and Macular Pigments Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 281 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Aleman, J. L. Duncan, M. L. Bieber, E. de Castro, D. A. Marks, L. M. Gardner, J. D. Steinberg, A. V. Cideciyan, M. G. Maguire, and S. G. Jacobson Macular Pigment and Lutein Supplementation in Retinitis Pigmentosa and Usher Syndrome Invest. Ophthalmol. Vis. Sci., July 1, 2001; 42(8): 1873 - 1881. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
