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(Investigative Ophthalmology and Visual Science. 2001;42:850-852.)
© 2001 by The Association for Research in Vision and Ophthalmology, Inc.

Localization of Caveolin-1 in Photoreceptor Synaptic Ribbons

Shu Kachi1, Akio Yamazaki2 and Jiro Usukura3,4

1 From the Departments of Ophthalmology and 2 Anatomy, Nagoya University, School of Medicine, Japan; and the 3 Departments of Ophthalmology and 4 Pharmacology, Kresge Eye Institute, Wayne State University, School of Medicine, Detroit, Michigan.

PURPOSE. The purpose of this study is to determine whether caveolin-1 is a constituent of photoreceptor synaptic ribbons.

METHODS. Immunoblot assay and electron microscopic immunocytochemistry were used to localize caveolin-1 in synaptic ribbons.

RESULTS. Synaptic ribbons were localized close to the active site of presynaptic membranes and surrounded by a halo of synaptic vesicles. Immunosignals of caveolin-1 were clearly detected on the synaptic ribbons in rod and cone photoreceptors. However, the signal was seen neither on synaptic vesicles nor on presynaptic plasma membranes.

CONCLUSIONS. Caveolin-1 is a component protein of synaptic ribbons and may be involved in the regulation of transmitter release.






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Copyright © 2001 by the Association for Research in Vision and Ophthalmology