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(Investigative Ophthalmology and Visual Science. 2001;42:1038-1044.)
© 2001 by The Association for Research in Vision and Ophthalmology, Inc.

Ocular Blood Flow and Retinal Metabolism in Abyssinian Cats with Hereditary Retinal Degeneration

Siv F. E. Nilsson1, Olav Mäepea2, Albert Alm2 and Kristina Narfström3

1 From the Departments of Physiology and 2 Neuroscience, Ophthalmology Division, University of Uppsala; and 3 Department of Medicine and Surgery, Swedish University of Agricultural Science, Uppsala, Sweden.

PURPOSE. To investigate if retinal blood flow decreases with progression of the disease in Abyssinian cats with progressive retinal atrophy (PRA), to examine if the choroidal blood flow was affected by the disease, and to determine the uptake of glucose and formation of lactate in the outer retina.

METHODS. Local blood flow in different parts of the eye was determined with radioactive microspheres, in 9 normal cats and in 10 cats at different stages of PRA. Three blood flow determinations were made in each animal, during control conditions, after IV administration of indomethacin and after subsequent administration of N{omega}-nitro-L-arginine (L-NA). Blood samples from a choroidal vein and a femoral artery were collected to determine the retinal formation of lactate and uptake of glucose.

RESULTS. In Abyssinian cats with PRA (n = 10), the retinal blood flow was significantly (P <= 0.01) lower than in normal cats (n = 9) during control conditions, 6.4 ± 1.7 compared with 14.1 ± 1.9 g min-1 (100 g)-1. The vascular resistance in the iris and ciliary body was significantly higher in the cats at a late stage of PRA, both compared with normal cats and to cats at an early stage of the disease, whereas the choroidal vascular resistance was not significantly affected. Indomethacin had no effect on ocular blood flows in normal cats, but in cats with PRA, iridal blood flow was more than doubled after indomethacin. The retinal formation of lactate was significantly (P <= 0.001) lower in cats with PRA than in normal cats, 0.111 ± 0.035 (n = 8) compared with 0.318 ± 0.024 (n = 8) µmol min-1. The uptake of glucose was not significantly different in cats with PRA.

CONCLUSIONS. Retinal blood flow is severely decreased in Abyssinian cats at a late stage of retinal degeneration, whereas the choroidal microcirculation is not significantly affected by the disease. At a late stage of retinal degeneration, vascular resistance in the iris is significantly increased, which at least in part could be caused by cyxlooxygenase products.




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L. Padnick-Silver, J. J. K. Derwent, E. Giuliano, K. Narfstrom, and R. A. Linsenmeier
Retinal oxygenation and oxygen metabolism in abyssinian cats with a hereditary retinal degeneration.
Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3683 - 3689.
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