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and TNF- Receptor-1 in the Retina of Normal and Glaucomatous Eyes
1 From the Departments of Ophthalmology and Visual Sciences and 2 Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri.
PURPOSE. To determine the expression and localization of tumor necrosis factor
(TNF)-
and TNF- receptor-1 in the retina of normal and
glaucomatous eyes.
METHODS. Using immunohistochemistry and in situ hybridization, retinal
expression and localization of TNF- and TNF- receptor-1 were
studied in retina sections from 20 eyes of donors with glaucoma, and 20
eyes of age-matched normal donors.
RESULTS. According to immunohistochemistry, the intensity of the immunostaining
and the number of labeled cells for TNF- or its receptor were
greater in retina sections of glaucomatous eyes than in control eyes of
age-matched normal donors. In situ hybridization showed that mRNA
signals for TNF- or TNF- receptor-1 were similarly more intense
in glaucomatous eyes than in age-matched control eyes. Both protein and
mRNA of TNF- or TNF- receptor-1 were predominantly localized to
the inner retinal layers. Double-immunofluorescence labeling
demonstrated that retinal immunostaining for TNF- was predominantly
positive in the glial cells, whereas immunostaining for TNF-
receptor-1 was mainly positive in the retinal ganglion cells.
CONCLUSIONS. Upregulation of TNF- and its receptor-1 in glaucomatous retina
suggest that TNF-–mediated cell death is involved in the
neurodegeneration process of glaucoma.
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