IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, R. F.
Right arrow Articles by Crawford, T. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, R. F.
Right arrow Articles by Crawford, T. O.
(Investigative Ophthalmology and Visual Science. 2002;43:686-691.)
© 2002 by The Association for Research in Vision and Ophthalmology, Inc.

Slow Target–Directed Eye Movements in Ataxia-Telangiectasia

Richard F. Lewis1,2 and Thomas O. Crawford3,4

1 From the Departments of Otolaryngology and 2 Neurology, Harvard Medical School, Boston, Massachusetts; and the 3 Departments of Neurology and 4 Pediatrics, Johns Hopkins Medical School, Baltimore, Maryland.

PURPOSE. To analyze the slow eye movements that shift the direction of gaze in patients with ataxia-telangiectasia (A-T).

METHODS. Eye and head movements were recorded with search coils in three patients with A-T during attempted gaze shifts, both with the head immobilized and free to move.

RESULTS. Gaze shifts frequently included both saccadic and slow components. The slow movements were recorded after 42% of saccades and had an average peak velocity of 6.1 deg/sec and a mean amplitude of 2.0°. They occurred with the head stationary and moving, could be directed centripetally or centrifugally, had velocity waveforms that were relatively linear or exponential, and always moved the eyes toward the visual target.

CONCLUSIONS. The slow movements appear to differ from pursuit and vestibular eye movements and are not fully explained by the various types of abnormal eye movements that can follow saccades, such as gaze-evoked nystagmus or postsaccadic drift. Their origin is uncertain, but they could represent very slow saccades, due to aberrant inhibition of burst cell activity during the saccade.




This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
A M R Taylor and P J Byrd
Molecular pathology of ataxia telangiectasia
J. Clin. Pathol., October 1, 2005; 58(10): 1009 - 1015.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the Association for Research in Vision and Ophthalmology