IOVS Journal of Virology
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(Investigative Ophthalmology and Visual Science. 2002;43:1142-1145.)
© 2002 by The Association for Research in Vision and Ophthalmology, Inc.

Effects of Topical Antiglaucoma Eye Drops on Prostaglandin E2–Induced Aqueous Flare Elevation in Pigmented Rabbits

Yoriko Hayasaka, Seiji Hayasaka, Xue-Yun Zhang and Yasunori Nagaki

From the Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.

PURPOSE. To evaluate the role of topical instillation of some antiglaucoma agents on experimental elevation of aqueous flare induced by prostaglandin E2 (PGE2) in pigmented rabbits.

METHODS. Transcorneal diffusion of PGE2 (25 µg/mL or 7.09 x 10-2 mM) with the use of a glass cylinder was achieved to produce aqueous flare elevation in pigmented rabbits. An antiglaucoma agent was topically administered before application of PGE2. Aqueous flare was measured with a laser flare cell meter.

RESULTS. A single instillation of apraclonidine 1.15%, two instillations of epinephrine 1.25%, two instillations of dipivefrin 0.1%, and two instillations and one instillation of dipivefrin 0.04% eye drops inhibited 98%, 96%, 87%, 73%, and 47% of PGE2-induced aqueous flare elevation, respectively. Timolol 0.5%, nipradilol 0.25%, dorzolamide 1%, and pilocarpine 2% eye drops had no effects on the increase of PGE2-induced flare.

CONCLUSIONS. Apraclonidine, epinephrine, and dipivefrin eye drops inhibit PGE2-induced elevation of aqueous flare in pigmented rabbits.




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Y. Hayasaka, S. Hayasaka, X.-Y. Zhang, and Y. Nagaki
Effects of Topical Anti-inflammatory and Antiallergic Eyedrops on Prostaglandin E2-Induced Aqueous Flare Elevation in Pigmented Rabbits
Arch Ophthalmol, July 1, 2002; 120(7): 950 - 953.
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Copyright © 2002 by the Association for Research in Vision and Ophthalmology