IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pawlyk, B. S.
Right arrow Articles by Berson, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pawlyk, B. S.
Right arrow Articles by Berson, E. L.
(Investigative Ophthalmology and Visual Science. 2002;43:1912-1915.)
© 2002 by The Association for Research in Vision and Ophthalmology, Inc.

Absence of Photoreceptor Rescue with D-cis-Diltiazem in the rd Mouse

Basil S. Pawlyk, Tiansen Li, Michael S. Scimeca, Michael A. Sandberg and Eliot L. Berson

From the Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.

PURPOSE. Because of a previous report suggesting that D-cis-diltiazem slows retinal degeneration in rd mice, this study was undertaken to examine the effect of D-cis-diltiazem on photoreceptor structure and function in this line of mice.

METHODS. Mice were randomly assigned to daily intraperitoneal injections of D-cis-diltiazem or saline between postnatal days 9 and 24. On postnatal day 26 or 27, retinal function was assessed by recording dark-adapted bright-flash ERGs in all animals. Retinal morphology was examined in fixed sections and in immunolabeled frozen sections. Examiners were masked to the treatment group assignment.

RESULTS. On postnatal days 26 and 27, diltiazem- and saline-treated mice had only one row of remaining photoreceptor cells throughout most of the central retina. Cone cells in the periphery had remnants of inner segments. Total cell counts and separate counts of rod and cone photoreceptor cells by immunostaining were similar in the diltiazem- versus saline-treated mice. Both groups of mice had, on average, comparable subnormal ERG amplitudes.

CONCLUSIONS. D-cis-Diltiazem had no detectable effect on preservation of photoreceptor structure and function in rd mice.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
G. Stearns, M. Evangelista, J. M. Fadool, and S. E. Brockerhoff
A Mutation in the Cone-Specific pde6 Gene Causes Rapid Cone Photoreceptor Degeneration in Zebrafish
J. Neurosci., December 12, 2007; 27(50): 13866 - 13874.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Sanges, A. Comitato, R. Tammaro, and V. Marigo
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors
PNAS, November 14, 2006; 103(46): 17366 - 17371.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
F. Doonan, M. Donovan, and T. G. Cotter
Activation of Multiple Pathways during Photoreceptor Apoptosis in the rd Mouse
Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3530 - 3538.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. J. Zeiss, J. Neal, and E. A. Johnson
Caspase-3 in Postnatal Retinal Development and Degeneration
Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 964 - 970.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the Association for Research in Vision and Ophthalmology