| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 From the Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands; the 2 Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands; 3 The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands; the 4 Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands; and the 5 Organization for Applied Scientific Research (TNO), Human Factors, Soesterberg, The Netherlands.
PURPOSE. It has been suggested that macular pigment (MP) and melanin may protect against age-related maculopathy (ARM). To check this, MP and melanin optical density were measured in a random population-based sample of subjects 55 years of age or older.
METHODS. Spectral fundus reflectance of the fovea was measured in one eye per subject in a 2.3° detection field with a fundus reflectometer. The sample consisted of 199 men and 236 women. Analysis with a fundus reflectance model yielded individual estimates for the MP and melanin optical density. Diagnosis of ARM was based on grading of standardized fundus transparencies. Eyes were stratified in four exclusive stages of ARM.
RESULTS. MP optical density (at 460 nm) was 0.33 ± 0.15 in eyes without ARM (n = 289) and 0.33 ± 0.16 in eyes at any stage of ARM (n = 146). Melanin optical density (at 500 nm) was 1.18 ± 0.19 in eyes without ARM and 1.20 ± 0.21 in eyes at any stage of ARM. We found no gender differences for either MP or melanin optical density.
CONCLUSIONS. No differences in MP and melanin optical density were found between eyes with and without ARM or between the various ARM stages.
This article has been cited by other articles:
|
|
 |
|
  M. J. Kanis, R. P. L. Wisse, T. T. J. M. Berendschot, J. van de Kraats, and D. van Norren Foveal Cone-Photoreceptor Integrity in Aging Macula Disorder Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2077 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S V Goverdhan, S Ennis, S R Hannan, K C Madhusudhana, A J Cree, A J Luff, and A J Lotery Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration Br. J. Ophthalmol., April 1, 2008; 92(4): 537 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. K. Wolf-Schnurrbusch, N. Roosli, E. Weyermann, M. R. Heldner, K. Hohne, and S. Wolf Ethnic Differences in Macular Pigment Density and Distribution Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3783 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R E Hogg, R S Anderson, M R Stevenson, M B Zlatkova, and U Chakravarthy In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry Br. J. Ophthalmol., April 1, 2007; 91(4): 485 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Mares, T. L LaRowe, D M. Snodderly, S. M Moeller, M. J Gruber, M. L Klein, B. R Wooten, E. J Johnson, R. J Chappell, and for the CAREDS Macular Pigment Study Group and Inv Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1107 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. J. M. Berendschot and D. van Norren Macular Pigment Shows Ringlike Structures Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Neelam, N. O'Gorman, J. Nolan, O. O'Donovan, H. B. Wong, K. G. A. Eong, and S. Beatty Measurement of Macular Pigment: Raman Spectroscopy versus Heterochromatic Flicker Photometry Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 1023 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nolan, O. O'Donovan, H. Kavanagh, J. Stack, M. Harrison, A. Muldoon, J. Mellerio, and S. Beatty Macular Pigment and Percentage of Body Fat Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3940 - 3950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Zarbin Current Concepts in the Pathogenesis of Age-Related Macular Degeneration Arch Ophthalmol, April 1, 2004; 122(4): 598 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Wang, K. G. Rendahl, W. C. Manning, D. Quiroz, M. Coyne, and S. S. Miller AAV-Mediated Expression of Vascular Endothelial Growth Factor Induces Choroidal Neovascularization in Rat Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 781 - 790. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
