HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Raz, D. Articles by Ofri, R. Search for Related Content PubMed PubMed Citation Articles by Raz, D. Articles by Ofri, R.

The Effect of Contrast and Luminance on mfERG Responses in a Monkey Model of Glaucoma

¹ From the Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel; the ² Retinal Electrodiagnostics Research Group, Department II, University Eye Hospital, Tübingen, Germany; the ³ Electrical and Computer Engineering Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel; ⁴ Novartis Ophthalmicus, Basel, Switzerland; and the ⁵ Department of Ophthalmology, Faculty of Medicine, Louis Pasteur University, Strasbourg, France.

PURPOSE. To evaluate the effect of contrast and luminance attenuation on the multifocal electroretinogram (mfERG) responses of normal and glaucomatous eyes of cynomolgus monkeys.

METHODS. Nine adult male cynomolgus monkeys with unilateral experimentally induced glaucoma were used. Hypertension-induced damage was confirmed by tomography of the optic disc. mfERGs were recorded with five different stimulus contrasts and/or luminance settings. The first-order and the first slice of second-order responses were analyzed.

RESULTS. Waveforms of normal and glaucomatous eyes differed in shape and amplitude. Second-order responses contributed to first-order responses of the signals in the normal eyes, but made a negligible contribution to the signals in the glaucomatous eyes. Contrast and luminance attenuation affected both first- and second-order responses. The differences between signals in normal and glaucomatous eyes were sufficiently large for an unsupervised clustering algorithm to achieve accurate segregation.

CONCLUSIONS. The observations in this study indicate that outer and inner retinal generators participate in first-order mfERG responses and that both inner and outer retinal contributors respond to contrast and luminance changes in stimulus. The hypertension-induced changes in the mfERG furthermore suggest damage to both inner and outer retina.

This article has been cited by other articles:

				P. H. W. Chu, H. H. L. Chan, and B. Brown Glaucoma detection is facilitated by luminance modulation of the global flash multifocal electroretinogram. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 929 - 937. [Abstract] [Full Text] [PDF]

				M. R. Lalonde, B. C. Chauhan, and F. Tremblay Retinal ganglion cell activity from the multifocal electroretinogram in pig: optic nerve section, anaesthesia and intravitreal tetrodotoxin J. Physiol., January 15, 2006; 570(2): 325 - 338. [Abstract] [Full Text] [PDF]

				B. Fortune, L. Wang, B. V. Bui, G. Cull, J. Dong, and G. A. Cioffi Local Ganglion Cell Contributions to the Macaque Electroretinogram Revealed by Experimental Nerve Fiber Layer Bundle Defect Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4567 - 4579. [Abstract] [Full Text] [PDF]

				D. Raz, I. Perlman, C. L. Percicot, G. N. Lambrou, and R. Ofri Functional Damage to Inner and Outer Retinal Cells in Experimental Glaucoma Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3675 - 3684. [Abstract] [Full Text] [PDF]