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(Investigative Ophthalmology and Visual Science. 2003;44:16-21.)
© 2003 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.02-0156
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Configuration of the Optic Chiasm in Humans with Albinism as Revealed by Magnetic Resonance Imaging

Bernd Schmitz,1 Torsten Schaefer,1 Christoph M. Krick,1 Wolfgang Reith,1 Martin Backens,1 and Barbara Käsmann-Kellner2

1From the Departments of Neuroradiology and 2Ophthalmology, Saarland University Hospital, Homburg, Germany.

PURPOSE. To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects.

METHODS. Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed with observer-independent morphometry and measurements by a blinded observer.

RESULTS. The albino group showed significantly smaller chiasmatic widths, smaller optic nerves and tracts, and wider angles between nerves and tracts. Statistical morphometry showed a different configuration of the optic chiasm.

CONCLUSIONS. Size and configuration of the optic chiasm in humans with albinism are distinctly different from those in normal control subjects and reflect the atypical crossing of optic fibers.




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