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(Investigative Ophthalmology and Visual Science. 2003;44:4920-4930.)
© 2003 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.02-1270
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Multifocal Electroretinograms in X-Linked Retinoschisis

Chang-Hua Piao, Mineo Kondo, Makoto Nakamura, Hiroko Terasaki, and Yozo Miyake

From the Department of Ophthalmology, Nagoya University School of Medicine, Showa-ku, Nagoya, Japan.

PURPOSE. To study local retinal cone function in patients with X-linked retinoschisis (XLRS) by multifocal ERGs (mfERGs).

METHODS. mfERGs were recorded from seven eyes of seven patients with XLRS (mean age ± SD, 22.1 ± 3.2 years; range, 18 to 25 years). Five eyes had microcystic changes in the macula and two eyes had nonspecific macular degeneration. Two eyes had peripheral retinoschisis, and some of the stimuli fell on this area. The stimulus array consisted of 103 hexagons and the total recording time was set at approximately 4 minutes. The amplitudes and implicit times of both focal and summed responses for the first- and second-order kernels were analyzed.

RESULTS. The amplitudes of the first-order kernel were markedly reduced in the central retina in all eyes. A large variation was observed in the amplitudes outside the fovea. The amplitudes of the focal cone ERGs at the peripheral retinoschisis did not differ from those recorded from adjacent retinal loci without the retinoschisis. The implicit times of the first-order kernel were significantly delayed, and the amplitudes of the second-order kernels were more affected than the first-order kernels across the whole field in all XLRS eyes.

CONCLUSIONS. The cone-mediated retinal responses were more impaired in the central than peripheral retina in eyes with XLRS. Delayed implicit times of the first-order kernel and reduced second-order kernel across the whole testing field in all XLRS eyes suggest that there is widespread cone-system dysfunction in XLRS.






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